Technology Process of 3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]phenyl}-2-fluoropropanoic acid
There total 7 articles about 3-{4-[(2',6'-dimethylbiphenyl-3-yl)methoxy]phenyl}-2-fluoropropanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hydroxide monohydrate; water;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 3h;
DOI:10.1021/jm101405t
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 6 h / 0 - 20 °C
2: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran
3: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 3 h / 20 °C
With
sodium tetrahydroborate; lithium hydroxide monohydrate; tributylphosphine; water; 1,1'-azodicarbonyl-dipiperidine;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane;
2: Mitsunobu reaction;
DOI:10.1021/jm101405t
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere
1.2: 3 h / 20 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol; water / 20 °C
3.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran
4.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 3 h / 20 °C
With
n-butyllithium; lithium hydroxide monohydrate; tributylphosphine; palladium 10% on activated carbon; water; hydrogen; 1,1'-azodicarbonyl-dipiperidine;
In
tetrahydrofuran; methanol; ethanol; hexane; water;
3.1: Mitsunobu reaction;
DOI:10.1021/jm101405t
