C₂₄H₃₂ClN₅O

Base Information

• Chemical Name: C₂₄H₃₂ClN₅O
• CAS No.: 1296885-72-7
• Molecular Formula: C₂₄H₃₂ClN₅O
• Molecular Weight: 442.004
• Mol file: 1296885-72-7.mol

Synonyms:

Chemical Property of C₂₄H₃₂ClN₅O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₃₂ClN₅O

There total 4 articles about C₂₄H₃₂ClN₅O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-bromoacetyl)piperidine (1796-25-4) + C17H21ClN4 → C24H32ClN5O (1296885-72-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2011.01.138

Reference yield:

C22H29ClN4O2 (1296885-71-6) → C24H32ClN5O (1296885-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.01.138

Reference yield:

4-chlorophenylethylamine (156-41-2) → C24H32ClN5O (1296885-72-7)

Guidance literature:

Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; xantphos; sodium t-butanolate / toluene / 100 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

3: triethylamine / N,N-dimethyl-formamide / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; xantphos; triethylamine; trifluoroacetic acid; sodium t-butanolate; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2011.01.138

upstream raw materials:

1-(2-bromoacetyl)piperidine

C₂₂H₂₉ClN₄O₂

4-chlorophenylethylamine

1-N-(tert-butoxycarbonyl)-4-N-(2-chloropyridin-4-yl)piperazine

Refernces