C₂₂H₁₉F₃N₆O

Base Information

Chemical Name:C₂₂H₁₉F₃N₆O
CAS No.:1294041-38-5
Molecular Formula:C₂₂H₁₉F₃N₆O
Molecular Weight:440.428
Hs Code.:

C<sub>22</sub>H<sub>19</sub>F<sub>3</sub>N<sub>6</sub>O

Synonyms:

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Chemical Property of C₂₂H₁₉F₃N₆O

Chemical Property:

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Technology Process of C₂₂H₁₉F₃N₆O

There total 7 articles about C₂₂H₁₉F₃N₆O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1293995-74-0
C₁₀H₁₆N₄O₂

: 1294041-38-5
C₂₂H₁₉F₃N₆O

Guidance literature:: Multi-step reaction with 6 steps

1: dimethyl sulfoxide / 150 °C

2: N-Bromosuccinimide / acetonitrile / 0 - 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / Reflux; Inert atmosphere

4: trifluoroacetic acid / dichloromethane

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

6: trifluoroacetic acid / dichloromethane

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; acetonitrile; 3: Suzuky-Miyaura coupling;
DOI:10.1016/j.bmcl.2011.01.086

Reference yield:

: 1251002-97-7
tert-butyl 3-bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazine-5(4H)-carboxylate

: 1294041-38-5
C₂₂H₁₉F₃N₆O

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / Reflux; Inert atmosphere

2: trifluoroacetic acid / dichloromethane

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

4: trifluoroacetic acid / dichloromethane

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; 1: Suzuky-Miyaura coupling;
DOI:10.1016/j.bmcl.2011.01.086

Reference yield:

: 1293995-86-4
C₁₇H₁₉N₅O₂

: 1294041-38-5
C₂₂H₁₉F₃N₆O

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

3: trifluoroacetic acid / dichloromethane

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2011.01.086