4-[(4,5-Dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-N,N-dimethyl-2-{[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl}benzenaminium Trifluoroacetate

Base Information

Chemical Name:4-[(4,5-Dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-N,N-dimethyl-2-{[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl}benzenaminium Trifluoroacetate
CAS No.:959839-51-1
Molecular Formula:C₂HF₃O₂*C₂₂H₂₄F₃N₇O₂
Molecular Weight:589.497
Hs Code.:

4-[(4,5-Dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-N,N-dimethyl-2-{[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl}benzenaminium Trifluoroacetate

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Chemical Property of 4-[(4,5-Dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-N,N-dimethyl-2-{[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl}benzenaminium Trifluoroacetate

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Technology Process of 4-[(4,5-Dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-N,N-dimethyl-2-{[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl}benzenaminium Trifluoroacetate

There total 3 articles about 4-[(4,5-Dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-N,N-dimethyl-2-{[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl}benzenaminium Trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 959839-50-0
4-[(4,5-dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-N,N-dimethyl-2-{[3-(trifluoromethyl)-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]carbonyl}benzenamine

: 76-05-1
trifluoroacetic acid

: 959839-51-1
4-[(4,5-Dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-N,N-dimethyl-2-{[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl}benzenaminium Trifluoroacetate

Guidance literature:: In water; acetonitrile;

Reference yield:

: 959841-61-3
5-[(6-chloro-4,5-dimethylpyridazin-3-yl)(cyano)methyl]-2-fluorobenzonitrile

: 959839-51-1
4-[(4,5-Dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-N,N-dimethyl-2-{[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl}benzenaminium Trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; water; acetic acid / 1.25 h / Heating / reflux

1.2: 20 °C

2.1: sodium acetate; acetic acid / 1 h / Heating / reflux

3.1: methanol; N,N-dimethyl-formamide / 1.5 h / 180 °C / Microwave irradiation

4.1: sodium hydroxide; water / 72 h / Heating / reflux

4.2: 20 °C / pH 4

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 20 °C

6.1: water; acetonitrile

With hydrogenchloride; sodium hydroxide; water; sodium acetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; water; N,N-dimethyl-formamide; acetonitrile;