Technology Process of C29H32F2N4O4
There total 8 articles about C29H32F2N4O4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl)(3,5-difluorobenzyl)amino)acetate;
With
hydrogenchloride;
In
ethanol;
at 0 ℃;
for 0.5h;
With
ammonium acetate;
In
ethanol;
at 20 ℃;
for 24h;
DOI:10.1016/j.bmcl.2011.06.089
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 48 h / Reflux
2.1: palladium on carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C
3.1: sodium triacetoxyborohydride / 1,2-dichloro-ethane / 6 h / 20 °C
4.1: N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate / acetonitrile / 24 h / 60 °C
5.1: hydrogenchloride / ethanol / 0.5 h / 0 °C
5.2: 24 h / 20 °C
With
hydrogenchloride; sodium triacetoxyborohydride; di-isopropyl azodicarboxylate; palladium on carbon; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; potassium carbonate; triphenylphosphine;
In
tetrahydrofuran; ethanol; 1,2-dichloro-ethane; acetonitrile;
1.1: Mitsunobu reaction / 5.1: Pinner reaction / 5.2: Pinner reaction;
DOI:10.1016/j.bmcl.2011.06.089
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: palladium on carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C
2.1: sodium triacetoxyborohydride / 1,2-dichloro-ethane / 6 h / 20 °C
3.1: N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate / acetonitrile / 24 h / 60 °C
4.1: hydrogenchloride / ethanol / 0.5 h / 0 °C
4.2: 24 h / 20 °C
With
hydrogenchloride; sodium triacetoxyborohydride; palladium on carbon; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; potassium carbonate;
In
tetrahydrofuran; ethanol; 1,2-dichloro-ethane; acetonitrile;
4.1: Pinner reaction / 4.2: Pinner reaction;
DOI:10.1016/j.bmcl.2011.06.089
