[4,5-(OC⁽²⁾H₃)2]-3-(benzyloxy)-4,5-dimethoxybenzyl bromide

Base Information

• Chemical Name: [4,5-(OC⁽²⁾H₃)2]-3-(benzyloxy)-4,5-dimethoxybenzyl bromide
• CAS No.: 651340-20-4
• Molecular Formula: C₁₆H₁₇BrO₃
• Molecular Weight: 343.166
• Mol file: 651340-20-4.mol

Synonyms:

Chemical Property of [4,5-(OC⁽²⁾H₃)2]-3-(benzyloxy)-4,5-dimethoxybenzyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4,5-(OC⁽²⁾H₃)2]-3-(benzyloxy)-4,5-dimethoxybenzyl bromide

There total 8 articles about [4,5-(OC⁽²⁾H₃)2]-3-(benzyloxy)-4,5-dimethoxybenzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H12(2)H6O4 → [4,5-(OC(2)H3)2]-3-(benzyloxy)-4,5-dimethoxybenzyl bromide (651340-20-4)

Guidance literature:

With phosphorus tribromide; In diethyl ether; at 20 ℃; for 1h;

DOI:10.1039/b304411d

Reference yield:

4-hydroxy-3-[2H3]methoxybenzaldehyde (74495-74-2) → [4,5-(OC(2)H3)2]-3-(benzyloxy)-4,5-dimethoxybenzyl bromide (651340-20-4)

Guidance literature:

Multi-step reaction with 8 steps

1: I₂; KI; aq. NaOH / 2 h / 20 °C

2: K₂CO₃ / dimethylformamide / 2 h / 20 °C

3: TsOH / methanol / 0.17 h / 0 °C

4: O₂; BuLi / diethyl ether / 0.67 h / -35 °C

5: aq. HCl / acetone / 0.08 h / 0 °C

6: K₂CO₃ / dimethylformamide / 4 h / 70 °C

7: NaBH₄ / methanol / 0.17 h / 20 °C

8: PBr₃ / diethyl ether / 1 h / 20 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; iodine; oxygen; phosphorus tribromide; potassium carbonate; toluene-4-sulfonic acid; potassium iodide; In methanol; diethyl ether; N,N-dimethyl-formamide; acetone;

DOI:10.1039/b304411d

Reference yield:

C8H4(2)H3IO3 → [4,5-(OC(2)H3)2]-3-(benzyloxy)-4,5-dimethoxybenzyl bromide (651340-20-4)

Guidance literature:

Multi-step reaction with 7 steps

1: K₂CO₃ / dimethylformamide / 2 h / 20 °C

2: TsOH / methanol / 0.17 h / 0 °C

3: O₂; BuLi / diethyl ether / 0.67 h / -35 °C

4: aq. HCl / acetone / 0.08 h / 0 °C

5: K₂CO₃ / dimethylformamide / 4 h / 70 °C

6: NaBH₄ / methanol / 0.17 h / 20 °C

7: PBr₃ / diethyl ether / 1 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; oxygen; phosphorus tribromide; potassium carbonate; toluene-4-sulfonic acid; In methanol; diethyl ether; N,N-dimethyl-formamide; acetone;

DOI:10.1039/b304411d

upstream raw materials:

4-hydroxy-3-[²H₃]methoxybenzaldehyde

C₁₁H₉⁽²⁾H₆IO₄