3-(4'-(methylsulfonyl)phenyl)-4-phenyl-1H-pyrrol-2(5H)-

Base Information

Chemical Name:3-(4'-(methylsulfonyl)phenyl)-4-phenyl-1H-pyrrol-2(5H)-
CAS No.:1337927-94-2
Molecular Formula:C₁₇H₁₅NO₃S
Molecular Weight:313.377
Hs Code.:

Synonyms:

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Chemical Property of 3-(4'-(methylsulfonyl)phenyl)-4-phenyl-1H-pyrrol-2(5H)-

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Technology Process of 3-(4'-(methylsulfonyl)phenyl)-4-phenyl-1H-pyrrol-2(5H)-

There total 9 articles about 3-(4'-(methylsulfonyl)phenyl)-4-phenyl-1H-pyrrol-2(5H)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1337927-92-0
3-(4'-(methylsulfonyl)phenyl)-4-phenyl-1H-pyrrole-2-carboxaldehyde

: 1337927-94-2
3-(4'-(methylsulfonyl)phenyl)-4-phenyl-1H-pyrrol-2(5H)-

Guidance literature:: With dihydrogen peroxide; sodium hydrogencarbonate; In methanol; at 20 ℃; Inert atmosphere;
DOI:10.1021/jo2013516

Reference yield:

: 3446-89-7
4-(Methylthio)benzaldehyde

: 1337927-94-2
3-(4'-(methylsulfonyl)phenyl)-4-phenyl-1H-pyrrol-2(5H)-

Guidance literature:: Multi-step reaction with 6 steps

1: benzene / Inert atmosphere; Reflux

2: acetic acid / methanol / 2.5 h / 20 °C / Inert atmosphere

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; isopropyl alcohol / 0 - 20 °C / Inert atmosphere

5: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

6: dihydrogen peroxide; sodium hydrogencarbonate / methanol / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; dihydrogen peroxide; sodium hydrogencarbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol; benzene; 2: modified Henry reaction / 3: Baeyer-Villiger-type oxidation / 4: Barton-Zard pyrrole reaction / 6: Baeyer-Villiger-type oxidation;
DOI:10.1021/jo2013516

Reference yield:

: 1337927-72-6
(Z)-1-bromo-2-[4'-(methylthio)phenyl]-1-nitroethene

: 1337927-94-2
3-(4'-(methylsulfonyl)phenyl)-4-phenyl-1H-pyrrol-2(5H)-

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 20 °C / Inert atmosphere; Reflux

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; isopropyl alcohol / 0 - 20 °C / Inert atmosphere

4: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

5: dihydrogen peroxide; sodium hydrogencarbonate / methanol / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dihydrogen peroxide; sodium hydrogencarbonate; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol; 1: Suzuki-Miyaura coupling / 2: Baeyer-Villiger-type oxidation / 3: Barton-Zard pyrrole reaction / 5: Baeyer-Villiger-type oxidation;
DOI:10.1021/jo2013516