C₁₉H₂₀N₂

Base Information

Chemical Name:C₁₉H₂₀N₂
CAS No.:1403376-90-8
Molecular Formula:C₁₉H₂₀N₂
Molecular Weight:276.381
Hs Code.:

C<sub>19</sub>H<sub>20</sub>N<sub>2</sub>

Synonyms:

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Chemical Property of C₁₉H₂₀N₂

Chemical Property:

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Technology Process of C₁₉H₂₀N₂

There total 10 articles about C₁₉H₂₀N₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₈N₂O₂

: 1403376-90-8
C₁₉H₂₀N₂

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h;
DOI:10.1021/jm3011299

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1403376-90-8
C₁₉H₂₀N₂

Guidance literature:: Multi-step reaction with 12 steps

1.1: Rh/Al₂O₃; hydrogen; acetic acid / methanol / 16 h / 2844.39 Torr

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -60 °C

2.2: 2 h / 0 °C

3.1: toluene-4-sulfonic acid / toluene / 3 h / Reflux

4.1: diisobutylaluminium hydride / dichloromethane; hexane / 1 h / -78 - -65 °C / Inert atmosphere

5.1: dichloromethane / 0.5 h / 20 °C

6.1: palladium(II) hydroxide; ammonium formate / ethanol / 2 h / Reflux

7.1: triethylamine; dmap / dichloromethane; ethanol / 0 - 20 °C

8.1: toluene-4-sulfonic acid / acetone / 20 °C

9.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - -60 °C

9.2: 4.5 h / -78 - -10 °C

10.1: 1,1'-bis-(diphenylphosphino)ferrocene; potassium acetate / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

11.1: potassium carbonate; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / 1,2-dimethoxyethane; water / 0.15 h / 106 °C / Inert atmosphere

12.1: trifluoroacetic acid / dichloromethane / 1 h

With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; oxalyl dichloride; Rh/Al₂O₃; hydrogen; ammonium formate; potassium acetate; palladium diacetate; palladium(II) hydroxide; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water; acetone; toluene; 2.1: |Swern Oxidation / 11.1: |Suzuki Coupling;
DOI:10.1021/jm3011299

Reference yield:

: 113474-25-2
5-hydroxy-cyclohexane-1,3-dicarboxylic acid dimethyl ester

: 1403376-90-8
C₁₉H₂₀N₂

Guidance literature:: Multi-step reaction with 11 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -60 °C

1.2: 2 h / 0 °C

2.1: toluene-4-sulfonic acid / toluene / 3 h / Reflux

3.1: diisobutylaluminium hydride / dichloromethane; hexane / 1 h / -78 - -65 °C / Inert atmosphere

4.1: dichloromethane / 0.5 h / 20 °C

5.1: palladium(II) hydroxide; ammonium formate / ethanol / 2 h / Reflux

6.1: triethylamine; dmap / dichloromethane; ethanol / 0 - 20 °C

7.1: toluene-4-sulfonic acid / acetone / 20 °C

8.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - -60 °C

8.2: 4.5 h / -78 - -10 °C

9.1: 1,1'-bis-(diphenylphosphino)ferrocene; potassium acetate / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

10.1: potassium carbonate; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / 1,2-dimethoxyethane; water / 0.15 h / 106 °C / Inert atmosphere

11.1: trifluoroacetic acid / dichloromethane / 1 h

With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; oxalyl dichloride; ammonium formate; potassium acetate; palladium diacetate; palladium(II) hydroxide; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water; acetone; toluene; 1.1: |Swern Oxidation / 10.1: |Suzuki Coupling;
DOI:10.1021/jm3011299