Technology Process of (5R,6S)-5-Acetoxy-6-<(E)-styryl>-5,6-dihydro-2H-pyran-2-one
There total 7 articles about (5R,6S)-5-Acetoxy-6-<(E)-styryl>-5,6-dihydro-2H-pyran-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium acetate; pyridinium chlorochromate;
In
dichloromethane;
for 1h;
Ambient temperature;
DOI:10.1039/P19900001733
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1) 1.5M BuLi / 1) THF, 2) THF, -78 deg C, 30 min
2: 19.1 percent / L-(+)-di-isopropyl tartrate, titanium tetraisopropoxide, t-butyl hydroperoxide, activated molecular sieves 3 Angstroem / CH2Cl2; various solvent(s) / 15 h / -25 °C
3: 32 percent / pyridinium toluene-p-sulphonate / CH2Cl2 / 1 h / Ambient temperature
4: 60 percent / NaBH4 / tetrahydrofuran; H2O / 3 h / 0 °C
5: 67 percent / 4-dimethylaminopyridine, pyridine / 3 h / Ambient temperature
6: 99 percent / 2M HCl / tetrahydrofuran / 10 h / 0 °C
7: 58 percent / pyridinium chlorochromate, NaOAc / CH2Cl2 / 1 h / Ambient temperature
With
pyridine; titanium(IV) isopropylate; hydrogenchloride; tert.-butylhydroperoxide; dmap; sodium tetrahydroborate; n-butyllithium; L-(+)-diisopropyl tartrate; 3 A molecular sieve; sodium acetate; pyridinium p-toluenesulfonate; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1039/P19900001733
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 32 percent / pyridinium toluene-p-sulphonate / CH2Cl2 / 1 h / Ambient temperature
2: 60 percent / NaBH4 / tetrahydrofuran; H2O / 3 h / 0 °C
3: 67 percent / 4-dimethylaminopyridine, pyridine / 3 h / Ambient temperature
4: 99 percent / 2M HCl / tetrahydrofuran / 10 h / 0 °C
5: 58 percent / pyridinium chlorochromate, NaOAc / CH2Cl2 / 1 h / Ambient temperature
With
pyridine; hydrogenchloride; dmap; sodium tetrahydroborate; sodium acetate; pyridinium p-toluenesulfonate; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1039/P19900001733
