2-{4-[1-(pyridin-2-yl)-1H-pyrazol-4-yl]phenyl}-2H-naphtho[1,2-d][1,2,3]triazole-6-sulfonic acid

Base Information

Chemical Name:2-{4-[1-(pyridin-2-yl)-1H-pyrazol-4-yl]phenyl}-2H-naphtho[1,2-d][1,2,3]triazole-6-sulfonic acid
CAS No.:1448581-69-8
Molecular Formula:C₂₄H₁₆N₆O₃S
Molecular Weight:468.495
Hs Code.:

Synonyms:

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Chemical Property of 2-{4-[1-(pyridin-2-yl)-1H-pyrazol-4-yl]phenyl}-2H-naphtho[1,2-d][1,2,3]triazole-6-sulfonic acid

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Technology Process of 2-{4-[1-(pyridin-2-yl)-1H-pyrazol-4-yl]phenyl}-2H-naphtho[1,2-d][1,2,3]triazole-6-sulfonic acid

There total 9 articles about 2-{4-[1-(pyridin-2-yl)-1H-pyrazol-4-yl]phenyl}-2H-naphtho[1,2-d][1,2,3]triazole-6-sulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₁₈N₆O₃S

: 1448581-69-8
2-{4-[1-(pyridin-2-yl)-1H-pyrazol-4-yl]phenyl}-2H-naphtho[1,2-d][1,2,3]triazole-6-sulfonic acid

Guidance literature:: With copper diacetate; In N,N-dimethyl-formamide; at 120 ℃;
DOI:10.1002/jhet.1697

Reference yield:

: 140-29-4
phenylacetonitrile

: 1448581-69-8
2-{4-[1-(pyridin-2-yl)-1H-pyrazol-4-yl]phenyl}-2H-naphtho[1,2-d][1,2,3]triazole-6-sulfonic acid

Guidance literature:: Multi-step reaction with 9 steps

1: nitric acid / 2 h / 0 - 40 °C

2: sulfuric acid / water / 0.5 h / 100 °C

3: trichlorophosphate / 12 h / 70 °C

4: sodium hydroxide / ethanol / 3 h / Reflux

5: ethanol / 5 h / Reflux

6: palladium 10% on activated carbon; hydrazine hydrate / ethanol / 1 h / Reflux

7: hydrogenchloride; sodium nitrite / water / 0 - 5 °C

8: sodium carbonate / water / 6 h / 10 - 70 °C / pH 6

9: copper diacetate / N,N-dimethyl-formamide / 120 °C

With hydrogenchloride; sulfuric acid; palladium 10% on activated carbon; nitric acid; copper diacetate; sodium carbonate; hydrazine hydrate; sodium hydroxide; sodium nitrite; trichlorophosphate; In ethanol; water; N,N-dimethyl-formamide; 3: |Vilsmeier-Haack Formylation;
DOI:10.1002/jhet.1697

Reference yield:

: 555-21-5,34512-13-5,174848-08-9
4-Nitrophenylacetonitrile

: 1448581-69-8
2-{4-[1-(pyridin-2-yl)-1H-pyrazol-4-yl]phenyl}-2H-naphtho[1,2-d][1,2,3]triazole-6-sulfonic acid

Guidance literature:: Multi-step reaction with 8 steps

1: sulfuric acid / water / 0.5 h / 100 °C

2: trichlorophosphate / 12 h / 70 °C

3: sodium hydroxide / ethanol / 3 h / Reflux

4: ethanol / 5 h / Reflux

5: palladium 10% on activated carbon; hydrazine hydrate / ethanol / 1 h / Reflux

6: hydrogenchloride; sodium nitrite / water / 0 - 5 °C

7: sodium carbonate / water / 6 h / 10 - 70 °C / pH 6

8: copper diacetate / N,N-dimethyl-formamide / 120 °C

With hydrogenchloride; sulfuric acid; palladium 10% on activated carbon; copper diacetate; sodium carbonate; hydrazine hydrate; sodium hydroxide; sodium nitrite; trichlorophosphate; In ethanol; water; N,N-dimethyl-formamide; 2: |Vilsmeier-Haack Formylation;
DOI:10.1002/jhet.1697