(2S)-N-[4-{1-(3-butoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-amino benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

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Chemical Name:(2S)-N-[4-{1-(3-butoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-amino benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal
CAS No.:1372097-29-4
Molecular Formula:C₂₉H₄₁N₅O₄S₂
Molecular Weight:587.808
Hs Code.:

Synonyms:

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Chemical Property of (2S)-N-[4-{1-(3-butoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-amino benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

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Technology Process of (2S)-N-[4-{1-(3-butoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-amino benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

There total 6 articles about (2S)-N-[4-{1-(3-butoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-amino benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 140647-02-5
(2S)-N-(4-hydroxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal

: 1372097-29-4
(2S)-N-[4-{1-(3-butoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-amino benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 48 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

2.2: 4 h / 0 - 20 °C

3.1: tin(II) chloride dihdyrate / methanol / 2 h / Reflux

With tin(II) chloride dihdyrate; sodium hydride; potassium carbonate; In methanol; N,N-dimethyl-formamide; acetone;
DOI:10.2174/157018012799129927

Reference yield:

: 52210-90-9
1-(pyridin-4-yl)-2-imidazolidinone

: 1372097-29-4
(2S)-N-[4-{1-(3-butoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-amino benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

1.2: 4 h / 0 - 20 °C

2.1: tin(II) chloride dihdyrate / methanol / 2 h / Reflux

With tin(II) chloride dihdyrate; sodium hydride; In methanol; N,N-dimethyl-formamide;
DOI:10.2174/157018012799129927

Reference yield:

: 504-24-5
4-aminopyridine

: 1372097-29-4
(2S)-N-[4-{1-(3-butoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-amino benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 5.5 h / 20 °C / Cooling with ice

2.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 4 h / 0 - 20 °C

4.1: tin(II) chloride dihdyrate / methanol / 2 h / Reflux

With tin(II) chloride dihdyrate; sodium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.2174/157018012799129927