C₂₀H₁₉N₅O₃

Base Information

• Chemical Name: C₂₀H₁₉N₅O₃
• CAS No.: 1374567-61-9
• Molecular Formula: C₂₀H₁₉N₅O₃
• Molecular Weight: 377.403
• Mol file: 1374567-61-9.mol

Synonyms:

Chemical Property of C₂₀H₁₉N₅O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₁₉N₅O₃

There total 1 articles about C₂₀H₁₉N₅O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4-methyl-6-nitroquinazoline (850172-44-0) + N-Benzoylpiperazine (13754-38-6) → C20H19N5O3 (1374567-61-9)

Guidance literature:

With triethylamine; In methanol; for 60h; Reflux;

DOI:10.1016/j.bmcl.2012.03.050

Reference yield:

C20H19N5O3 (1374567-61-9) → C20H21N5O (1374567-76-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 2h;

DOI:10.1016/j.bmcl.2012.03.050

Reference yield:

C20H19N5O3 (1374567-61-9) → C28H26ClN5O3 (1374567-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 2 h

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 20 °C

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2012.03.050

upstream raw materials:

2-chloro-4-methyl-6-nitroquinazoline

N-Benzoylpiperazine

Downstream raw materials:

C₂₀H₂₁N₅O

C₂₈H₂₆ClN₅O₃