Technology Process of C28H29N3O
There total 3 articles about C28H29N3O which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N'-(3-phenylpropylidene)benzohydrazide;
With
C14H22ClNO2Si;
In
4-methyl-1,2,3-trifluorobenzene;
at 23 ℃;
for 0.5h;
Inert atmosphere;
C18H27NSi;
In
4-methyl-1,2,3-trifluorobenzene;
at -20 ℃;
for 15h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ol201566u
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
1.2: 15 h / -78 - 20 °C / Inert atmosphere
2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / 0.17 h / -78 °C / Inert atmosphere
2.2: 3 h / -78 - 20 °C / Inert atmosphere
3.1: C14H22ClNO2Si / 4-methyl-1,2,3-trifluorobenzene / 0.5 h / 23 °C / Inert atmosphere
3.2: 15 h / -20 °C / Inert atmosphere
With
n-butyllithium; C14H22ClNO2Si; diisopropylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; hexanes; 4-methyl-1,2,3-trifluorobenzene;
3.1: Mannich reaction / 3.2: Mannich reaction;
DOI:10.1021/ol201566u
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / 0.17 h / -78 °C / Inert atmosphere
1.2: 3 h / -78 - 20 °C / Inert atmosphere
2.1: C14H22ClNO2Si / 4-methyl-1,2,3-trifluorobenzene / 0.5 h / 23 °C / Inert atmosphere
2.2: 15 h / -20 °C / Inert atmosphere
With
n-butyllithium; C14H22ClNO2Si; diisopropylamine;
In
tetrahydrofuran; hexanes; 4-methyl-1,2,3-trifluorobenzene;
2.1: Mannich reaction / 2.2: Mannich reaction;
DOI:10.1021/ol201566u
