2-(3-fluoro-4-methylphenyl)propan-2-amine

Base Information

• Chemical Name: 2-(3-fluoro-4-methylphenyl)propan-2-amine
• CAS No.: 1314663-93-8
• Molecular Formula: C₁₀H₁₄FN
• Molecular Weight: 167.226
• Mol file: 1314663-93-8.mol

Synonyms:

Chemical Property of 2-(3-fluoro-4-methylphenyl)propan-2-amine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-fluoro-4-methylphenyl)propan-2-amine

There total 2 articles about 2-(3-fluoro-4-methylphenyl)propan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-(3-fluoro-4-methylphenyl)propan-2-ol (1379326-22-3) → 2-(3-fluoro-4-methylphenyl)propan-2-amine (1314663-93-8)

Guidance literature:

2-(3-fluoro-4-methylphenyl)propan-2-ol; With sodium azide; trifluoroacetic acid; In dichloromethane; at -5 - 20 ℃; for 0.25h; Inert atmosphere;

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 3h;

DOI:10.1021/acs.orglett.7b03152

Reference yield:

1-(3-fluoro-4-methylphenyl)ethan-1-one (42444-14-4) → 2-(3-fluoro-4-methylphenyl)propan-2-amine (1314663-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diethyl ether / 0 °C

2.1: sodium azide; trifluoroacetic acid / dichloromethane / 0.25 h / -5 - 20 °C / Inert atmosphere

2.2: 3 h / 20 °C

With sodium azide; trifluoroacetic acid; In diethyl ether; dichloromethane;

DOI:10.1021/acs.orglett.7b03152

upstream raw materials:

1-(3-fluoro-4-methylphenyl)ethan-1-one

2-(3-fluoro-4-methylphenyl)propan-2-ol