Technology Process of 6-cyclohexyl-N-[(S)-2-oxoazetidin-3-yl]hexanamide
There total 4 articles about 6-cyclohexyl-N-[(S)-2-oxoazetidin-3-yl]hexanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
1.2: 16 h / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / ethanol / 45 °C / 15001.5 Torr / Flow reactor
3.1: lithium hydroxide / tetrahydrofuran; ethanol; water / 1 h
3.2: pH 3
4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane; N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere
4.2: 16 h / 20 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; lithium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
1.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1002/cmdc.201300546
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
2.2: 16 h / Inert atmosphere
3.1: palladium 10% on activated carbon; hydrogen / ethanol / 45 °C / 15001.5 Torr / Flow reactor
4.1: lithium hydroxide / tetrahydrofuran; ethanol; water / 1 h
4.2: pH 3
5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane; N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere
5.2: 16 h / 20 °C / Inert atmosphere
With
oxalyl dichloride; palladium 10% on activated carbon; hydrogen; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; dimethyl sulfoxide; triethylamine; lithium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
2.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1002/cmdc.201300546
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon; hydrogen / ethanol / 45 °C / 15001.5 Torr / Flow reactor
2.1: lithium hydroxide / tetrahydrofuran; ethanol; water / 1 h
2.2: pH 3
3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane; N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere
3.2: 16 h / 20 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; lithium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201300546
