C₁₅H₁₁F₃N₂O

Base Information

• Chemical Name: C₁₅H₁₁F₃N₂O
• CAS No.: 1803416-28-5
• Molecular Formula: C₁₅H₁₁F₃N₂O
• Molecular Weight: 292.26
• Mol file: 1803416-28-5.mol

Synonyms:

Chemical Property of C₁₅H₁₁F₃N₂O

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₁F₃N₂O

There total 2 articles about C₁₅H₁₁F₃N₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

(–)-(S)-N-(2-hydroxy-1-phenylethyl)-5-(trifluoromethyl)picolinamide → C15H11F3N2O (1803416-28-5,1835671-08-3)

Guidance literature:

With diethylamino-sulfur trifluoride; potassium carbonate; In dichloromethane; at -78 ℃; for 1h;

DOI:10.1039/c9cc03775f

Reference yield:

(2S)-2-phenylglycinol (20989-17-7) + 5-(trifluoromethyl)picolinic acid (80194-69-0) → C15H11F3N2O (1803416-28-5,1835671-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.33 h / 0 °C

1.2: 16 h / 0 - 20 °C

2.1: diethylamino-sulfur trifluoride; potassium carbonate / dichloromethane / 1 h / -78 °C

With 4-methyl-morpholine; diethylamino-sulfur trifluoride; potassium carbonate; isobutyl chloroformate; In dichloromethane;

DOI:10.1039/c9cc03775f

upstream raw materials:

(2S)-2-phenylglycinol

5-(trifluoromethyl)picolinic acid