1-((4-methyl-2-phenylthiazol-5-yl)methyleneamino)-2-ethylisothiourea

Base Information

• Chemical Name: 1-((4-methyl-2-phenylthiazol-5-yl)methyleneamino)-2-ethylisothiourea
• CAS No.: 1453840-22-6
• Molecular Formula: C₁₄H₁₆N₄S₂
• Molecular Weight: 304.44
• Mol file: 1453840-22-6.mol

Synonyms:

Chemical Property of 1-((4-methyl-2-phenylthiazol-5-yl)methyleneamino)-2-ethylisothiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-((4-methyl-2-phenylthiazol-5-yl)methyleneamino)-2-ethylisothiourea

There total 4 articles about 1-((4-methyl-2-phenylthiazol-5-yl)methyleneamino)-2-ethylisothiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-methyl-2-phenyl-1,3-thiazol-5-yl) methanol (61291-91-6) → 1-((4-methyl-2-phenylthiazol-5-yl)methyleneamino)-2-ethylisothiourea (1453840-22-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 °C

2: methanol / 2 h

3: acetone / Alkaline conditions; Reflux

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In methanol; dimethyl sulfoxide; acetone;

DOI:10.1080/10426507.2012.745542

Reference yield:

4-methyl-2-phenyl-thiazole-5-carboxylic acid ethyl ester (53715-64-3) → 1-((4-methyl-2-phenylthiazol-5-yl)methyleneamino)-2-ethylisothiourea (1453840-22-6)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / diethyl ether / 1.5 h / 0 °C

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 °C

3: methanol / 2 h

4: acetone / Alkaline conditions; Reflux

With lithium aluminium tetrahydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In methanol; diethyl ether; dimethyl sulfoxide; acetone;

DOI:10.1080/10426507.2012.745542

Reference yield:

1-((2-phenyl)-4-methylthiazol-5-yl)methylene thiosemicarbazide (1453840-18-0) → 1-((4-methyl-2-phenylthiazol-5-yl)methyleneamino)-2-ethylisothiourea (1453840-22-6)

Guidance literature:

In acetone; Alkaline conditions; Reflux;

DOI:10.1080/10426507.2012.745542

upstream raw materials:

1-((2-phenyl)-4-methylthiazol-5-yl)methylene thiosemicarbazide

4-methyl-2-phenyl-thiazole-5-carboxylic acid ethyl ester

(4-methyl-2-phenyl-1,3-thiazol-5-yl) methanol

4-methyl-2-phenylthiazole-5-carbaldehyde

Refernces