(R,E)-2,2,2-trifluoro-N-phenethyl-N-(1-phenylhex-4-en-3-yl)acetamide

Base Information

• Chemical Name: (R,E)-2,2,2-trifluoro-N-phenethyl-N-(1-phenylhex-4-en-3-yl)acetamide
• CAS No.: 1246567-10-1
• Molecular Formula: C₂₂H₂₄F₃NO
• Molecular Weight: 375.434
• Mol file: 1246567-10-1.mol

Synonyms:

Chemical Property of (R,E)-2,2,2-trifluoro-N-phenethyl-N-(1-phenylhex-4-en-3-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,E)-2,2,2-trifluoro-N-phenethyl-N-(1-phenylhex-4-en-3-yl)acetamide

There total 3 articles about (R,E)-2,2,2-trifluoro-N-phenethyl-N-(1-phenylhex-4-en-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-6-phenylhex-3-en-2-yl 2,2,2-trifluoro-N-phenethylacetimidate → (R,E)-6-phenylhex-3-en-2-yl 2,2,2-trifluoro-N-phenethylacetimidate + (R,E)-2,2,2-trifluoro-N-phenethyl-N-(1-phenylhex-4-en-3-yl)acetamide (1246567-10-1)

Guidance literature:

With C₉₂H₇₆Cl₂Fe₂N₂O₂Pd₂; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; silver nitrate; In dichloromethane; at 20 ℃; for 10h; optical yield given as %ee; Inert atmosphere; Darkness;

DOI:10.1002/asia.201000386

Reference yield:

(E)-6-phenyl-3-hexen-2-one (33046-41-2,56161-62-7) → (R,E)-6-phenylhex-3-en-2-yl 2,2,2-trifluoro-N-phenethylacetimidate + (R,E)-2,2,2-trifluoro-N-phenethyl-N-(1-phenylhex-4-en-3-yl)acetamide (1246567-10-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / dichloromethane / 5 h / -78 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: C₉₂H₇₆Cl₂Fe₂N₂O₂Pd₂; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; silver nitrate / dichloromethane / 10 h / 20 °C / Inert atmosphere; Darkness

With C₉₂H₇₆Cl₂Fe₂N₂O₂Pd₂; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; sodium hydride; diisobutylaluminium hydride; silver nitrate; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1002/asia.201000386

Reference yield:

(E)-6-phenyl-2-hydroxy-hex-3-ene (56539-56-1,113768-03-9,130700-03-7,130700-02-6) → (R,E)-6-phenylhex-3-en-2-yl 2,2,2-trifluoro-N-phenethylacetimidate + (R,E)-2,2,2-trifluoro-N-phenethyl-N-(1-phenylhex-4-en-3-yl)acetamide (1246567-10-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: C₉₂H₇₆Cl₂Fe₂N₂O₂Pd₂; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; silver nitrate / dichloromethane / 10 h / 20 °C / Inert atmosphere; Darkness

With C₉₂H₇₆Cl₂Fe₂N₂O₂Pd₂; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; sodium hydride; silver nitrate; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1002/asia.201000386

upstream raw materials:

(E)-6-phenyl-3-hexen-2-one

(E)-6-phenyl-2-hydroxy-hex-3-ene