BI-224436

Base Information

Chemical Name:BI-224436
CAS No.:1155419-89-8
Molecular Formula:C₂₇H₂₆N₂O₄
Molecular Weight:442.514
Hs Code.:
Mol file:1155419-89-8.mol

Synonyms:

Suppliers and Price of BI-224436

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
BI-224436 >98%
10 mg
$ 400.00

DC Chemicals
BI-224436 >98%
100 mg
$ 1680.00

DC Chemicals
BI-224436 >98%
50 mg
$ 1200.00

Crysdot
BI224436 98+%
50mg
$ 1050.00

Crysdot
BI224436 98+%
5mg
$ 245.00

ChemScene
BI224436 98.17%
10mg
$ 600.00

ChemScene
BI224436 98.17%
5mg
$ 420.00

ChemScene
BI224436 98.17%
50mg
$ 1800.00

ChemScene
BI224436 98.17%
100mg
$ 2520.00

Biorbyt Ltd
BI-224436
100 mg
$ 2512.60

Total 4 raw suppliers

Chemical Property of BI-224436

Chemical Property:

Boiling Point:631.8±55.0 °C(Predicted)
PKA:0.81±0.30(Predicted)
Density:1.277±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

BI-224436 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of BI-224436

There total 30 articles about BI-224436 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1402714-51-5
C₂₈H₂₈N₂O₄

: 1155419-89-8
BI-224436

Guidance literature:: C₂₈H₂₈N₂O₄; With ethanol; sodium hydroxide; at 20 - 65 ℃; Inert atmosphere; Industry scale;

With hydrogenchloride; In water; at 50 - 55 ℃; pH=5 - 5.5;

Reference yield: 93.0%

: 1402714-51-5
methyl 2-(tert-butoxy)-2-((R)-4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetate

: 1155419-89-8
2-(tert-butoxy)-2-((R)-4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; at 20 - 60 ℃; for 1h; Inert atmosphere;
DOI:10.1002/anie.201501575

Reference yield:

: 542-05-2
acetonedicarboxylic acid

: 1155419-89-8
BI-224436

Guidance literature:: Multi-step reaction with 9 steps

1.1: 40 °C / Inert atmosphere

2.1: fluorobenzene / 4 h / 35 - 37 °C / Inert atmosphere

2.2: 2.5 h / 23 - 45 °C

3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / isopropyl alcohol; toluene; tetrahydrofuran / 4.5 h / 0 - 25 °C

3.2: 40 °C

4.1: trichlorophosphate / acetonitrile / 65 - 75 °C

5.1: trifluoroacetic acid; zinc / 1 h / 60 - 70 °C

6.1: n-butyllithium / toluene; hexane / 1 h / -50 - -45 °C

6.2: 0.5 h / 10 °C / Industry scale

6.3: 0.5 h / 10 - 20 °C

7.1: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (S)-3-tert-butyl-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole / water; pentan-1-ol / 60 - 63 °C / Industry scale; Inert atmosphere

8.1: bis(trifluoromethanesulfonyl)amide / dichloromethane; fluorobenzene / 35 - 41 °C / Inert atmosphere; Industry scale

9.1: sodium hydroxide; ethanol / 20 - 65 °C / Inert atmosphere; Industry scale

9.2: 50 - 55 °C / pH 5 - 5.5

With n-butyllithium; ethanol; sodium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; trifluoroacetic acid; sodium hydroxide; zinc; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (S)-3-tert-butyl-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole; bis(trifluoromethanesulfonyl)amide; In tetrahydrofuran; fluorobenzene; hexane; dichloromethane; pentan-1-ol; water; isopropyl alcohol; toluene; acetonitrile; 7.1: Suzuki Coupling;