Technology Process of 8-[7-(methoxycarbonyl)-3-heptenylidene]-2-(p-toluenesulfonyl)-2-azabicyclo[3.3.1]nonane
There total 8 articles about 8-[7-(methoxycarbonyl)-3-heptenylidene]-2-(p-toluenesulfonyl)-2-azabicyclo[3.3.1]nonane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 20 °C
2.1: water; trimethylphosphane / tetrahydrofuran / 70 °C
3.1: triethylamine / dichloromethane / 4 h / 0 °C / Inert atmosphere
4.1: Dess-Martin periodane / dichloromethane / 20 °C
5.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 3 h / Inert atmosphere
5.2: 1.5 h / Inert atmosphere
With
water; potassium hexamethylsilazane; Dess-Martin periodane; triethylamine; 3-chloro-benzenecarboperoxoic acid; trimethylphosphane;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ol301672y
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: water; trimethylphosphane / tetrahydrofuran / 70 °C
2.1: triethylamine / dichloromethane / 4 h / 0 °C / Inert atmosphere
3.1: Dess-Martin periodane / dichloromethane / 20 °C
4.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 3 h / Inert atmosphere
4.2: 1.5 h / Inert atmosphere
With
water; potassium hexamethylsilazane; Dess-Martin periodane; triethylamine; trimethylphosphane;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ol301672y
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium tetrahydroborate; 2-methyl-but-2-ene; boron trifluoride diethyl etherate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
3.1: sodium azide / N,N-dimethyl-formamide / 3 h / 60 °C
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 20 °C
5.1: water; trimethylphosphane / tetrahydrofuran / 70 °C
6.1: triethylamine / dichloromethane / 4 h / 0 °C / Inert atmosphere
7.1: Dess-Martin periodane / dichloromethane / 20 °C
8.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 3 h / Inert atmosphere
8.2: 1.5 h / Inert atmosphere
With
sodium tetrahydroborate; sodium azide; 2-methyl-but-2-ene; boron trifluoride diethyl etherate; water; potassium hexamethylsilazane; Dess-Martin periodane; triethylamine; 3-chloro-benzenecarboperoxoic acid; trimethylphosphane;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol301672y
