(R)-4-(2-methoxy-5-methylphenyl)-4-phenylbutan-1-ol

Base Information

Chemical Name:(R)-4-(2-methoxy-5-methylphenyl)-4-phenylbutan-1-ol
CAS No.:1416165-64-4
Molecular Formula:C₁₈H₂₂O₂
Molecular Weight:270.371
Hs Code.:

Synonyms:

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Chemical Property of (R)-4-(2-methoxy-5-methylphenyl)-4-phenylbutan-1-ol

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Technology Process of (R)-4-(2-methoxy-5-methylphenyl)-4-phenylbutan-1-ol

There total 7 articles about (R)-4-(2-methoxy-5-methylphenyl)-4-phenylbutan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₃₅BO

: 1416165-64-4
(R)-4-(2-methoxy-5-methylphenyl)-4-phenylbutan-1-ol

Guidance literature:: With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 2h;
DOI:10.1139/v2012-069

Reference yield:

: 613-84-3
2-hydroxy-5-methylbenzaldehyde

: 1416165-64-4
(R)-4-(2-methoxy-5-methylphenyl)-4-phenylbutan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate

2.1: Inert atmosphere; Schlenk technique

3.1: triethylamine / toluene / 2 h / 150 °C / Inert atmosphere

4.1: sec.-butyllithium / diethyl ether; cyclohexane; hexane / 1 h / -78 °C / Inert atmosphere; Schlenk technique

4.2: 2 h / -78 °C / Inert atmosphere; Schlenk technique

4.3: 16.08 h / -78 - 20 °C / Inert atmosphere; Schlenk technique

5.1: tetrabutyl ammonium fluoride; water / toluene / 1.5 h / 20 °C

6.1: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Schlenk technique

7.1: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 2 h / 0 - 20 °C

With tetrabutyl ammonium fluoride; water; dihydrogen peroxide; sec.-butyllithium; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; diethyl ether; hexane; cyclohexane; water; toluene;
DOI:10.1139/v2012-069

Reference yield:

: 7083-19-4
2-methoxy-5-methylbenzaldehyde

: 1416165-64-4
(R)-4-(2-methoxy-5-methylphenyl)-4-phenylbutan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: Inert atmosphere; Schlenk technique

2.1: triethylamine / toluene / 2 h / 150 °C / Inert atmosphere

3.1: sec.-butyllithium / diethyl ether; cyclohexane; hexane / 1 h / -78 °C / Inert atmosphere; Schlenk technique

3.2: 2 h / -78 °C / Inert atmosphere; Schlenk technique

3.3: 16.08 h / -78 - 20 °C / Inert atmosphere; Schlenk technique

4.1: tetrabutyl ammonium fluoride; water / toluene / 1.5 h / 20 °C

5.1: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Schlenk technique

6.1: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 2 h / 0 - 20 °C

With tetrabutyl ammonium fluoride; water; dihydrogen peroxide; sec.-butyllithium; triethylamine; sodium hydroxide; In tetrahydrofuran; diethyl ether; hexane; cyclohexane; water; toluene;
DOI:10.1139/v2012-069