2-[3-cyano-4-((E)-2-{5-[(E)-3-(2,6-diphenyl-4H-pyran-4-ylidene)prop-1-enyl]thiophen-2-yl}vinyl)-5,5-dimethylfuran-2(5H)-ylidene]malononitrile

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Chemical Name:2-[3-cyano-4-((E)-2-{5-[(E)-3-(2,6-diphenyl-4H-pyran-4-ylidene)prop-1-enyl]thiophen-2-yl}vinyl)-5,5-dimethylfuran-2(5H)-ylidene]malononitrile
CAS No.:1374127-01-1
Molecular Formula:C₃₆H₂₅N₃O₂S
Molecular Weight:563.679
Hs Code.:

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Chemical Property of 2-[3-cyano-4-((E)-2-{5-[(E)-3-(2,6-diphenyl-4H-pyran-4-ylidene)prop-1-enyl]thiophen-2-yl}vinyl)-5,5-dimethylfuran-2(5H)-ylidene]malononitrile

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Technology Process of 2-[3-cyano-4-((E)-2-{5-[(E)-3-(2,6-diphenyl-4H-pyran-4-ylidene)prop-1-enyl]thiophen-2-yl}vinyl)-5,5-dimethylfuran-2(5H)-ylidene]malononitrile

There total 4 articles about 2-[3-cyano-4-((E)-2-{5-[(E)-3-(2,6-diphenyl-4H-pyran-4-ylidene)prop-1-enyl]thiophen-2-yl}vinyl)-5,5-dimethylfuran-2(5H)-ylidene]malononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374126-91-6
(E)-4-[3-(5-bromothiophen-2-yl)allylidene]-2,6-diphenyl-4H-pyran

: 1374127-01-1
2-[3-cyano-4-((E)-2-{5-[(E)-3-(2,6-diphenyl-4H-pyran-4-ylidene)prop-1-enyl]thiophen-2-yl}vinyl)-5,5-dimethylfuran-2(5H)-ylidene]malononitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / Inert atmosphere

1.2: 1 h

2.1: pyridine; acetic acid / ethanol / 24 h / Reflux

With pyridine; n-butyllithium; acetic acid; In tetrahydrofuran; ethanol; hexane; 2.1: Knoevenagel condensation;
DOI:10.1021/jo300373m

Reference yield:

: (E)-3-(5-bromothiophen-2-yl)acrylaldehyde

: 1374127-01-1
2-[3-cyano-4-((E)-2-{5-[(E)-3-(2,6-diphenyl-4H-pyran-4-ylidene)prop-1-enyl]thiophen-2-yl}vinyl)-5,5-dimethylfuran-2(5H)-ylidene]malononitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / Inert atmosphere

1.2: 5 h

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / Inert atmosphere

2.2: 1 h

3.1: pyridine; acetic acid / ethanol / 24 h / Reflux

With pyridine; n-butyllithium; acetic acid; In tetrahydrofuran; ethanol; hexane; 1.1: Horner-Wadsworth-Emmons olefination / 1.2: Horner-Wadsworth-Emmons olefination / 3.1: Knoevenagel condensation;
DOI:10.1021/jo300373m

Reference yield:

: 129806-51-5
2,6-diphenyl-(4H-pyran-4ylidene)-diphenylphosphine oxide

: 1374127-01-1
2-[3-cyano-4-((E)-2-{5-[(E)-3-(2,6-diphenyl-4H-pyran-4-ylidene)prop-1-enyl]thiophen-2-yl}vinyl)-5,5-dimethylfuran-2(5H)-ylidene]malononitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / Inert atmosphere

1.2: 5 h

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / Inert atmosphere

2.2: 1 h

3.1: pyridine; acetic acid / ethanol / 24 h / Reflux

With pyridine; n-butyllithium; acetic acid; In tetrahydrofuran; ethanol; hexane; 1.1: Horner-Wadsworth-Emmons olefination / 1.2: Horner-Wadsworth-Emmons olefination / 3.1: Knoevenagel condensation;
DOI:10.1021/jo300373m