methyl 4-(((S)-5-((3,5-bis(trifluoromethyl)-benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)-cyclohexane-1-carboxylate

Base Information

Chemical Name:methyl 4-(((S)-5-((3,5-bis(trifluoromethyl)-benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)-cyclohexane-1-carboxylate
CAS No.:1259393-26-4
Molecular Formula:C₃₂H₃₈F₆N₆O₂
Molecular Weight:652.683
Hs Code.:

methyl 4-(((S)-5-((3,5-bis(trifluoromethyl)-benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)-cyclohexane-1-carboxylate

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Chemical Property of methyl 4-(((S)-5-((3,5-bis(trifluoromethyl)-benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)-cyclohexane-1-carboxylate

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Technology Process of methyl 4-(((S)-5-((3,5-bis(trifluoromethyl)-benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)-cyclohexane-1-carboxylate

There total 3 articles about methyl 4-(((S)-5-((3,5-bis(trifluoromethyl)-benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)-cyclohexane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259393-19-5
(5S)-N-(3,5-bis(trifluoromethyl)benzyl)-7,9-dimethyl-N-(2-methyl-2H-tetrazol-5-yl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-amine

: 54274-80-5
trans-4-formyl-cyclohexanecarboxylic acid methyl ester

: 1259393-26-4
methyl 4-(((S)-5-((3,5-bis(trifluoromethyl)-benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)-cyclohexane-1-carboxylate

Guidance literature:: (5S)-N-(3,5-bis(trifluoromethyl)benzyl)-7,9-dimethyl-N-(2-methyl-2H-tetrazol-5-yl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-amine; trans-4-formyl-cyclohexanecarboxylic acid methyl ester; With platinum on carbon; hydrogen; acetic acid; In tetrahydrofuran; at 25 ℃; for 16h; under 2585.81 Torr;

With hydrogen; In tetrahydrofuran; at 35 ℃; for 2h; Reagent/catalyst;
DOI:10.1021/op500025v

Reference yield:

: 1259393-19-5
(5S)-N-(3,5-bis(trifluoromethyl)benzyl)-7,9-dimethyl-N-(2-methyl-2H-tetrazol-5-yl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-amine

: 54274-80-5
trans-4-formyl-cyclohexanecarboxylic acid methyl ester

: 1259393-26-4
methyl 4-(((S)-5-((3,5-bis(trifluoromethyl)-benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)-cyclohexane-1-carboxylate

: 1587704-14-0
C₃₂H₃₈F₆N₆O₂

Guidance literature:: With hydrogen; acetic acid; platinum; In water; at 0 - 35 ℃; for 18h; under 2585.81 Torr; Solvent; Reagent/catalyst; Temperature; Overall yield = 88 %; Inert atmosphere;
DOI:10.1021/op500025v

Reference yield:

: sodium hydroxy[trans-4-(methoxycarbonyl)cyclohexyl]methanesulfonate

: 1259393-26-4
methyl 4-(((S)-5-((3,5-bis(trifluoromethyl)-benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)-cyclohexane-1-carboxylate

: 1587704-14-0
C₃₂H₃₈F₆N₆O₂

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium carbonate / toluene / 3 h / 25 °C / Inert atmosphere

2: platinum; acetic acid; hydrogen / water / 18 h / 0 - 35 °C / 2585.81 Torr / Inert atmosphere

With water; hydrogen; sodium carbonate; acetic acid; platinum; In water; toluene;
DOI:10.1021/op500025v