Methyl 6-hydroxypyrazine-2-carboxylate

Base Information

• Chemical Name: Methyl 6-hydroxypyrazine-2-carboxylate
• CAS No.: 13924-98-6
• Molecular Formula: C6H6N2O3
• Molecular Weight: 154.12300
• Hs Code.: 2933990090
• Mol file: 13924-98-6.mol

Synonyms:6-oxo-1,6-dihydro-pyrazine-2-carboxylic acid methyl ester;6-Hydroxy-pyrazin-2-carbonsaeure-methyl-ester;QC-6880;methyl 6-hydroxypyrazine-2-carboxylate;6-Hydroxy-2-methoxycarbonylpyrazin;Methyl 6-hydroxy-2-pyrazinecarboxylate;

Chemical Property of Methyl 6-hydroxypyrazine-2-carboxylate

Chemical Property:

• PSA: 72.05000
• LogP: -0.44350

Purity/Quality:

99% ^*data from raw suppliers

Methyl6-hydroxypyrazine-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 6-hydroxypyrazine-2-carboxylate

There total 5 articles about Methyl 6-hydroxypyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

methyl 3-carboxy-1,6-dihydro-6-oxo-2-pyrazinecarboxylate (73403-51-7) → methyl 1,6-dihydro-6-oxo-2-pyrazinecarboxylate (13924-98-6)

Guidance literature:

With nitrobenzene; at 180 - 190 ℃; for 7h;

DOI:10.1248/cpb.28.3057

Reference yield:

1,6-dihydro-6-oxo-2,3-pyrazinedicarbonitrile (57005-60-4) → methyl 1,6-dihydro-6-oxo-2-pyrazinecarboxylate (13924-98-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 30 percent / conc. HCl / Ambient temperature

2: 1.) 10percent NaOH; 2.) SOCl₂ / 1.) reflux, 5 h; 2.) reflux, 3 h

3: 5 h / Heating

4: 56 percent / nitrobenzene / 7 h / 180 - 190 °C

With hydrogenchloride; sodium hydroxide; thionyl chloride; nitrobenzene;

DOI:10.1248/cpb.28.3057

Reference yield:

1H-furo<3,4-b>pyrazine-2,5,7-trione (73403-50-6) → methyl 1,6-dihydro-6-oxo-2-pyrazinecarboxylate (13924-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 5 h / Heating

2: 56 percent / nitrobenzene / 7 h / 180 - 190 °C

With nitrobenzene;

DOI:10.1248/cpb.28.3057

upstream raw materials:

methyl 3-carboxy-1,6-dihydro-6-oxo-2-pyrazinecarboxylate

1,6-dihydro-6-oxo-2,3-pyrazinedicarbonitrile

1H-furo<3,4-b>pyrazine-2,5,7-trione

1,6-dihydro-6-oxo-2,3-pyrazinedicarboxamide

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