((S)-2,2-difluorocyclopropyl)-((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone p-toluenesulfonic acid salt

Base Information

Chemical Name:((S)-2,2-difluorocyclopropyl)-((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone p-toluenesulfonic acid salt
CAS No.:2140301-96-6
Molecular Formula:(x)C₇H₈O₃S*C₁₈H₂₁F₂N₇O
Molecular Weight:
Hs Code.:

((S)-2,2-difluorocyclopropyl)-((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone p-toluenesulfonic acid salt

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((S)-2,2-difluorocyclopropyl)-((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone p-toluenesulfonic acid salt

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of ((S)-2,2-difluorocyclopropyl)-((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone p-toluenesulfonic acid salt

There total 10 articles about ((S)-2,2-difluorocyclopropyl)-((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone p-toluenesulfonic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-N-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine

: 2,2-difluorocyclopropane-1-(S)-carboxylate (R)-N-Benzyl-1-phenylethan-1-aminium salt

: 104-15-4
toluene-4-sulfonic acid

: 2140301-96-6
((S)-2,2-difluorocyclopropyl)-((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone p-toluenesulfonic acid salt

Guidance literature:: 2,2-difluorocyclopropane-1-(S)-carboxylate (R)-N-Benzyl-1-phenylethan-1-aminium salt; With sulfuric acid; In tert-butyl methyl ether; water monomer; at 25 ℃;

4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-N-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine; With 2-hydroxy-pyridine N-oxide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; water monomer; at 0 ℃;

toluene-4-sulfonic acid; In tetrahydrofuran; water monomer; for 4h;

Reference yield:

: 1883299-62-4
((S)-2,2-difluorocyclopropyl)-((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone

: 104-15-4
toluene-4-sulfonic acid

: 2140301-96-6
((S)-2,2-difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone 4-methylbenzenesulfonate

Guidance literature:: With water; In acetonitrile; at 20 ℃;
DOI:10.1021/acs.jmedchem.8b00917

Reference yield:

: 4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-N-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine

: isoquinolin-3-yl (S)-2,2-difluorocyclopropane-1-carboxylate

: 104-15-4
toluene-4-sulfonic acid

: 2140301-96-6
((S)-2,2-difluorocyclopropyl)-((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone p-toluenesulfonic acid salt

Guidance literature:: 4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-N-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-amine; isoquinolin-3-yl (S)-2,2-difluorocyclopropane-1-carboxylate; With 2-hydroxy-pyridine N-oxide; In tetrahydrofuran; water monomer; at 20 ℃;

toluene-4-sulfonic acid; In tetrahydrofuran; water monomer; at 50 ℃;