(+)-pinanediol (1R)-2-[3-(tert-butoxycarbonyl)phenyl]-1-{(αR)-α-[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonylamino]-4-hydroxybenzenacetylamino}ethaneboronate

Base Information

• Chemical Name: (+)-pinanediol (1R)-2-[3-(tert-butoxycarbonyl)phenyl]-1-{(αR)-α-[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonylamino]-4-hydroxybenzenacetylamino}ethaneboronate
• CAS No.: 1421842-15-0
• Molecular Formula: C₃₈H₄₉BN₄O₉
• Molecular Weight: 716.639
• Mol file: 1421842-15-0.mol

Synonyms:

Chemical Property of (+)-pinanediol (1R)-2-[3-(tert-butoxycarbonyl)phenyl]-1-{(αR)-α-[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonylamino]-4-hydroxybenzenacetylamino}ethaneboronate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-pinanediol (1R)-2-[3-(tert-butoxycarbonyl)phenyl]-1-{(αR)-α-[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonylamino]-4-hydroxybenzenacetylamino}ethaneboronate

There total 1 articles about (+)-pinanediol (1R)-2-[3-(tert-butoxycarbonyl)phenyl]-1-{(αR)-α-[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonylamino]-4-hydroxybenzenacetylamino}ethaneboronate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H34BNO4 + (R)-<<(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl>amino>(4-hydroxyphenyl)acetic acid (62893-24-7,79868-75-0) → (+)-pinanediol (1R)-2-[3-(tert-butoxycarbonyl)phenyl]-1-{(αR)-α-[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonylamino]-4-hydroxybenzenacetylamino}ethaneboronate (1421842-15-0)

Guidance literature:

(R)-<<(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl>amino>(4-hydroxyphenyl)acetic acid; With isobutyl chloroformate; In tetrahydrofuran; at -35 - -10 ℃; for 0.166667h; Inert atmosphere;

With 4-methyl-morpholine; In tetrahydrofuran; at -10 ℃; for 1h; Inert atmosphere;

C₂₃H₃₄BNO₄; In tetrahydrofuran; at -10 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm301490d

Reference yield:

(+)-pinanediol (1R)-2-[3-(tert-butoxycarbonyl)phenyl]-1-{(αR)-α-[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonylamino]-4-hydroxybenzenacetylamino}ethaneboronate (1421842-15-0) → C34H41BN4O9 (1429254-89-6)

Guidance literature:

With methoxybenzene; trifluoroacetic acid; In dichloromethane; at -10 - 20 ℃; for 3.16667h; Inert atmosphere;

DOI:10.1021/jm301490d

upstream raw materials:

(R)-<<(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl>amino>(4-hydroxyphenyl)acetic acid

Downstream raw materials:

C₃₄H₄₁BN₄O₉