N-[2-(2-{4-[1-((R)-2-hydroxy-propyl)piperidin-4-yl]-2-methoxyphenylamino}pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl]-N-methylmethanesulfonamide

Base Information

Chemical Name:N-[2-(2-{4-[1-((R)-2-hydroxy-propyl)piperidin-4-yl]-2-methoxyphenylamino}pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl]-N-methylmethanesulfonamide
CAS No.:1233144-90-5
Molecular Formula:C₂₉H₃₆N₆O₄S
Molecular Weight:564.709
Hs Code.:

N-[2-(2-{4-[1-((R)-2-hydroxy-propyl)piperidin-4-yl]-2-methoxyphenylamino}pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl]-N-methylmethanesulfonamide

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Chemical Property of N-[2-(2-{4-[1-((R)-2-hydroxy-propyl)piperidin-4-yl]-2-methoxyphenylamino}pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl]-N-methylmethanesulfonamide

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Technology Process of N-[2-(2-{4-[1-((R)-2-hydroxy-propyl)piperidin-4-yl]-2-methoxyphenylamino}pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl]-N-methylmethanesulfonamide

There total 7 articles about N-[2-(2-{4-[1-((R)-2-hydroxy-propyl)piperidin-4-yl]-2-methoxyphenylamino}pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl]-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1233143-37-7
C₁₄H₁₄N₄O₃S

: 1233144-90-5
N-[2-(2-{4-[1-((R)-2-hydroxy-propyl)piperidin-4-yl]-2-methoxyphenylamino}pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl]-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: N,N-dimethyl-formamide / Heating

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm2010767

Reference yield:

: 1233145-65-7
4-(3-methoxy-4-nitro-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1233144-90-5
N-[2-(2-{4-[1-((R)-2-hydroxy-propyl)piperidin-4-yl]-2-methoxyphenylamino}pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl]-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: methanol

3: palladium 10% on activated carbon; hydrogen / methanol / 2.5 h / 2585.81 Torr

4: N,N-dimethyl-formamide / Heating

With methanol; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm2010767

Reference yield:

: 1116228-85-3
4-(3-methoxy-4-nitro-phenyl)-1,2,3,6-tetrahydropyridine

: 1233144-90-5
N-[2-(2-{4-[1-((R)-2-hydroxy-propyl)piperidin-4-yl]-2-methoxyphenylamino}pyrrolo[2,1-f][1,2,4]triazin-7-yl)phenyl]-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: methanol

2: palladium 10% on activated carbon; hydrogen / methanol / 2.5 h / 2585.81 Torr

3: N,N-dimethyl-formamide / Heating

With methanol; palladium 10% on activated carbon; hydrogen; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm2010767