H-Phe-SEt

Base Information

• Chemical Name: H-Phe-SEt
• CAS No.: 1454706-35-4
• Molecular Formula: C₁₁H₁₅NOS
• Molecular Weight: 209.312
• Mol file: 1454706-35-4.mol

Synonyms:

Chemical Property of H-Phe-SEt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of H-Phe-SEt

There total 2 articles about H-Phe-SEt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

S-ethyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanethioate (292150-93-7) → H-Phe-SEt (1454706-35-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c8ob02901f

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → H-Phe-SEt (1454706-35-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 2 h / 25 °C / Inert atmosphere

With chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1039/c8ob02901f

Reference yield:

N-(tert-butyloxycarbonyl)-L-isoleucine (13139-16-7) + H-Phe-SEt (1454706-35-4) → C22H34N2O4S

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 25 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c8ob02901f

upstream raw materials:

N-tert-butoxycarbonyl-L-phenylalanine

S-ethyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanethioate