C₂₅H₄₆O₅Si₂

Base Information

• Chemical Name: C₂₅H₄₆O₅Si₂
• CAS No.: 1608472-90-7
• Molecular Formula: C₂₅H₄₆O₅Si₂
• Molecular Weight: 482.808
• Mol file: 1608472-90-7.mol

Synonyms:

Chemical Property of C₂₅H₄₆O₅Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₄₆O₅Si₂

There total 8 articles about C₂₅H₄₆O₅Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S,4S)-2,3-bis[(tert-butyldimethylsilyl)oxy]-4-[(4-methoxybenzyl)oxy]pentan-1-ol (1608472-96-3) → C25H46O5Si2 (1608472-90-7)

Guidance literature:

(2R,3S,4S)-2,3-bis[(tert-butyldimethylsilyl)oxy]-4-[(4-methoxybenzyl)oxy]pentan-1-ol; With oxalyl dichloride; In dichloromethane; dimethyl sulfoxide; at -78 ℃; for 1.5h; Inert atmosphere;

With triethylamine; In dichloromethane; dimethyl sulfoxide; at -78 - 0 ℃; for 1h; regioselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201301215

Reference yield:

(-)-(2E)-(4S)-ethyl 4-(p-methoxybenzyl)oxy-2-pentenoate → C25H46O5Si2 (1608472-90-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / dichloromethane / 1 h / 0 °C / Inert atmosphere

2.1: titanium(IV) isopropylate; L-(+)-diisopropyl tartrate / dichloromethane / 0.5 h / -20 °C / Inert atmosphere; Molecular sieve

2.2: 8 h / Inert atmosphere

3.1: sodium hydroxide / water; tert-butyl alcohol / 15 h / 70 °C / Inert atmosphere

4.1: 1H-imidazole / dichloromethane; N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

5.1: toluene-4-sulfonic acid / methanol / 0.5 h / -15 °C / Inert atmosphere

6.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1.5 h / -78 °C / Inert atmosphere

6.2: 1 h / -78 - 0 °C / Inert atmosphere

With 1H-imidazole; titanium(IV) isopropylate; oxalyl dichloride; L-(+)-diisopropyl tartrate; diisobutylaluminium hydride; toluene-4-sulfonic acid; sodium hydroxide; In methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol; 2.1: |Sharpless Asymmetric Epoxidation / 2.2: |Sharpless Allylic Amination;

DOI:10.1002/ejoc.201301215

Reference yield:

(5S,6R)-6-[(tert-butyldimethylsilyl)oxy]-5-{(S)-1-[(4-methoxybenzyl)oxy]ethyl}-2,2,3,3,9,9,10,10-octamethyl-4,8-dioxa-3,9-disilaundecane (1608472-95-2) → C25H46O5Si2 (1608472-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / methanol / 0.5 h / -15 °C / Inert atmosphere

2.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1.5 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 - 0 °C / Inert atmosphere

With oxalyl dichloride; toluene-4-sulfonic acid; In methanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1002/ejoc.201301215

upstream raw materials:

((2S,3S)-3-{(S)-1-[(4-methoxybenzyl)oxy]ethyl}oxiran-2-yl)methanol

(5S,6R)-6-[(tert-butyldimethylsilyl)oxy]-5-{(S)-1-[(4-methoxybenzyl)oxy]ethyl}-2,2,3,3,9,9,10,10-octamethyl-4,8-dioxa-3,9-disilaundecane

(2R,3S,4S)-2,3-bis[(tert-butyldimethylsilyl)oxy]-4-[(4-methoxybenzyl)oxy]pentan-1-ol

(S)-2-O-(4'-methoxybenzyl)propan-1,2-diol

Downstream raw materials:

(5S,6R,7R)-6-[(tert-butyldimethylsilyl)oxy]-5-{(S)-1-[(4-methoxybenzyl)oxy]ethyl}-2,2,3,3,12,12,13,13-octamethyl-4,11-dioxa-3,12-disilatetradec-8-yn-7-ol