13-hydroxy acetyl-10-deacetyl baccatin III

Base Information

• Chemical Name: 13-hydroxy acetyl-10-deacetyl baccatin III
• CAS No.: 110258-97-4
• Molecular Formula: C₃₁H₃₈O₁₂
• Molecular Weight: 602.636
• Mol file: 110258-97-4.mol

Synonyms:

Chemical Property of 13-hydroxy acetyl-10-deacetyl baccatin III

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 13-hydroxy acetyl-10-deacetyl baccatin III

There total 5 articles about 13-hydroxy acetyl-10-deacetyl baccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C37H38Cl6O16 (110259-03-5) → 13-hydroxy acetyl-10-deacetyl baccatin III (110258-97-4)

Guidance literature:

With zinc; In acetic acid; at 60 ℃; for 1h;

DOI:10.1016/S0040-4020(01)87285-9

Reference yield:

10-deacetylbaccatin III (32981-86-5,172018-16-5) → 13-hydroxy acetyl-10-deacetyl baccatin III (110258-97-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 153 mg / pyridine / 0.08 h / 80 °C

2: 42 mg / 1.) oxalyl chloride; 2.) silver cyanide / toluene / 20 h / 110 °C

3: 115 mg / osmium tetroxide / pyridine / 1 h / Ambient temperature

4: 309 mg / lead tetraacetate / acetic acid / 0.5 h / Ambient temperature

5: 20 mg / Zn dust / acetic acid / 1 h / 60 °C

With lead(IV) acetate; osmium(VIII) oxide; silver cyanide; oxalyl dichloride; zinc; In pyridine; acetic acid; toluene;

DOI:10.1016/S0040-4020(01)87285-9

Reference yield:

7,10-di(2,2,2-trichloroethyloxy-carbonyl)-13-cinnamoyl-10-deacetyl baccatin III (95603-45-5,110281-75-9) → 13-hydroxy acetyl-10-deacetyl baccatin III (110258-97-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 115 mg / osmium tetroxide / pyridine / 1 h / Ambient temperature

2: 309 mg / lead tetraacetate / acetic acid / 0.5 h / Ambient temperature

3: 20 mg / Zn dust / acetic acid / 1 h / 60 °C

With lead(IV) acetate; osmium(VIII) oxide; zinc; In pyridine; acetic acid;

DOI:10.1016/S0040-4020(01)87285-9

upstream raw materials:

C₃₇H₃₈Cl₆O₁₆

10-deacetylbaccatin III

7,10-di(2,2,2-trichloroethyloxy-carbonyl)-13-cinnamoyl-10-deacetyl baccatin III

7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III