Technology Process of C19H17F3N2O
There total 5 articles about C19H17F3N2O which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
water;
at 80 ℃;
for 3h;
DOI:10.1021/jm400009c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid; silica gel / neat (no solvent) / 180 °C / Microwave irradiation
2.1: trichlorophosphate / 0.25 h / 20 °C / Inert atmosphere
2.2: 3 h / 100 °C / Inert atmosphere
3.1: potassium hydrogensulfate / ethanol / 3 h / 70 - 80 °C
4.1: hydrogenchloride / water / 3 h / 80 °C
With
hydrogenchloride; potassium hydrogensulfate; silica gel; toluene-4-sulfonic acid; trichlorophosphate;
In
ethanol; water;
1.1: |Paal-Knorr Pyrrole Synthesis / 2.2: |Vilsmeier-Haack Formylation;
DOI:10.1021/jm400009c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid; silica gel / neat (no solvent) / 180 °C / Microwave irradiation
2.1: trichlorophosphate / 0.25 h / 20 °C / Inert atmosphere
2.2: 3 h / 100 °C / Inert atmosphere
3.1: potassium hydrogensulfate / ethanol / 3 h / 70 - 80 °C
4.1: hydrogenchloride / water / 3 h / 80 °C
With
hydrogenchloride; potassium hydrogensulfate; silica gel; toluene-4-sulfonic acid; trichlorophosphate;
In
ethanol; water;
1.1: |Paal-Knorr Pyrrole Synthesis / 2.2: |Vilsmeier-Haack Formylation;
DOI:10.1021/jm400009c
