(2R,3R,4R,5R,6R)-2-phenylazepane-3,4,5,6-tetraol

Base Information

Chemical Name:(2R,3R,4R,5R,6R)-2-phenylazepane-3,4,5,6-tetraol
CAS No.:1427017-15-9
Molecular Formula:C₁₂H₁₇NO₄
Molecular Weight:239.271
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R,4R,5R,6R)-2-phenylazepane-3,4,5,6-tetraol

Chemical Property:

Purity/Quality:

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Technology Process of (2R,3R,4R,5R,6R)-2-phenylazepane-3,4,5,6-tetraol

There total 5 articles about (2R,3R,4R,5R,6R)-2-phenylazepane-3,4,5,6-tetraol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1427017-09-1
(2R,3R,4R,5R,6R)-3,4,5,6-tetrakis(benzyloxy)-2-phenylazepan-1-ol

: 1427017-15-9
(2R,3R,4R,5R,6R)-2-phenylazepane-3,4,5,6-tetraol

Guidance literature:: With hydrogenchloride; methanol; palladium 10% on activated carbon; hydrogen;
DOI:10.1021/jo400130p

Reference yield:

: 110578-68-2
2,3,4,5-tetrakis-benzyloxyhexane-1,6-diol

: 1427017-15-9
(2R,3R,4R,5R,6R)-2-phenylazepane-3,4,5,6-tetraol

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 20 °C

1.2: 24 h / Reflux

2.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / Reflux

2.2: Reflux

3.1: oxone; sodium hydrogencarbonate; edetate disodium / tetrahydrofuran; acetonitrile / 3 h / 0 °C

4.1: tetrahydrofuran; diethyl ether / 0 °C / Inert atmosphere

5.1: palladium 10% on activated carbon; hydrogen; hydrogenchloride; methanol

With hydrogenchloride; methanol; carbonochloridic acid 1-chloro-ethyl ester; oxone; palladium 10% on activated carbon; hydrogen; edetate disodium; sodium hydrogencarbonate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jo400130p

Reference yield:

: 1427016-47-4
(3R,4R,5R,6R)-1-allyl-3,4,5,6-tetrakis(benzyloxy)azepane

: 1427017-15-9
(2R,3R,4R,5R,6R)-2-phenylazepane-3,4,5,6-tetraol

Guidance literature:: Multi-step reaction with 4 steps

1.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / Reflux

1.2: Reflux

2.1: oxone; sodium hydrogencarbonate; edetate disodium / tetrahydrofuran; acetonitrile / 3 h / 0 °C

3.1: tetrahydrofuran; diethyl ether / 0 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen; hydrogenchloride; methanol

With hydrogenchloride; methanol; carbonochloridic acid 1-chloro-ethyl ester; oxone; palladium 10% on activated carbon; hydrogen; edetate disodium; sodium hydrogencarbonate; In tetrahydrofuran; diethyl ether; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jo400130p