(3R,4R,5S)-4-ethyl-3-fluoro-5-(hydroxymethyl)pyrrolidin-2-one

Base Information

Chemical Name:(3R,4R,5S)-4-ethyl-3-fluoro-5-(hydroxymethyl)pyrrolidin-2-one
CAS No.:1817630-30-0
Molecular Formula:C₇H₁₂FNO₂
Molecular Weight:161.176
Hs Code.:

Synonyms:

Suppliers and Price of (3R,4R,5S)-4-ethyl-3-fluoro-5-(hydroxymethyl)pyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of (3R,4R,5S)-4-ethyl-3-fluoro-5-(hydroxymethyl)pyrrolidin-2-one

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (3R,4R,5S)-4-ethyl-3-fluoro-5-(hydroxymethyl)pyrrolidin-2-one

There total 16 articles about (3R,4R,5S)-4-ethyl-3-fluoro-5-(hydroxymethyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: (6S,7S,7aS)-7-ethyl-6-fluoro-3,3-dimethyltetrahydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one

: 1817630-30-0
(3S,4S,5S)-4-ethyl-3-fluoro-5-(hydroxymethyl)-pyrrolidin-2-one

Guidance literature:: With toluene-4-sulfonic acid; In water; acetonitrile; at 90 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b00231

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 1817630-30-0
(3S,4S,5S)-4-ethyl-3-fluoro-5-(hydroxymethyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / toluene / 16 h / 120 °C

2.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.58 h / -70 - -25 °C

2.2: 0.42 h / -70 - -10 °C

3.1: palladium diacetate / tetrahydrofuran / 8 h / 65 °C

4.1: chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.5 h / -70 - -10 °C

4.2: 0.5 h / 0 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

5.2: 0.5 h / -78 °C

6.1: trifluoroacetic acid / water; acetonitrile / 4 h / -65 °C

With n-butyllithium; chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex; palladium diacetate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; water; toluene; acetonitrile;

Reference yield:

: 99208-71-6
(5S)-1-aza-2,2-dimethyl-3-oxa-8-oxo-bicyclo[3.3.0]octane

: 1817630-30-0
(3S,4S,5S)-4-ethyl-3-fluoro-5-(hydroxymethyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -70 - -20 °C / Inert atmosphere

1.2: -60 - -10 °C / Inert atmosphere

2.1: palladium diacetate; allyl methyl carbonate / tetrahydrofuran / 1 h / 65 °C

3.1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran; diethyl ether / 1 h / -30 - -20 °C / Inert atmosphere; Industrial scale

3.2: 1 h / -70 - -3 °C / Inert atmosphere; Industrial scale

3.3: Industrial scale

4.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1 h / -70 - -20 °C / Inert atmosphere

4.2: -72 - 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / acetonitrile; water / 4 h / 65 °C / Inert atmosphere

With n-butyllithium; copper(I) bromide dimethylsulfide complex; allyl methyl carbonate; palladium diacetate; diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; hexane; water; acetonitrile;