8-benzamido-N-(5-(5-(3-(dimethylamino)propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl)-1-methyl-1H-pyrrol-3-yl)quinoline-2-carboxamide

Base Information

• Chemical Name: 8-benzamido-N-(5-(5-(3-(dimethylamino)propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl)-1-methyl-1H-pyrrol-3-yl)quinoline-2-carboxamide
• CAS No.: 1383563-92-5
• Molecular Formula: C₃₄H₃₆N₈O₄
• Molecular Weight: 620.711
• Mol file: 1383563-92-5.mol

Synonyms:

Chemical Property of 8-benzamido-N-(5-(5-(3-(dimethylamino)propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl)-1-methyl-1H-pyrrol-3-yl)quinoline-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-benzamido-N-(5-(5-(3-(dimethylamino)propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl)-1-methyl-1H-pyrrol-3-yl)quinoline-2-carboxamide

There total 6 articles about 8-benzamido-N-(5-(5-(3-(dimethylamino)propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl)-1-methyl-1H-pyrrol-3-yl)quinoline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

C17H11ClN2O2 (1383563-99-2) + 4-{[(4-amino-1-methyl-1H-pyrrol-2-yl)carbonyl]amino}-N-[3-(dimethylamino)propyl]-1-methyl-1H-pyrrole-2-carboxamide (78486-16-5) → 8-benzamido-N-(5-(5-(3-(dimethylamino)propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl)-1-methyl-1H-pyrrol-3-yl)quinoline-2-carboxamide (1383563-92-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2012.05.001

Reference yield:

C18H14N2O3 (1383563-94-7) → 8-benzamido-N-(5-(5-(3-(dimethylamino)propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl)-1-methyl-1H-pyrrol-3-yl)quinoline-2-carboxamide (1383563-92-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

2: thionyl chloride / benzene / Inert atmosphere; Reflux

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With thionyl chloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; benzene;

DOI:10.1016/j.tet.2012.05.001

Reference yield:

C17H12N2O3 (1383563-96-9) → 8-benzamido-N-(5-(5-(3-(dimethylamino)propylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl)-1-methyl-1H-pyrrol-3-yl)quinoline-2-carboxamide (1383563-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / benzene / Inert atmosphere; Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; benzene;

DOI:10.1016/j.tet.2012.05.001

upstream raw materials:

C₁₈H₁₄N₂O₃

C₁₇H₁₂N₂O₃

C₁₇H₁₁ClN₂O₂

4-{[(4-amino-1-methyl-1H-pyrrol-2-yl)carbonyl]amino}-N-[3-(dimethylamino)propyl]-1-methyl-1H-pyrrole-2-carboxamide