C₁₄H₁₁FN₂O

Base Information

• Chemical Name: C₁₄H₁₁FN₂O
• CAS No.: 1370000-29-5
• Molecular Formula: C₁₄H₁₁FN₂O
• Molecular Weight: 242.253
• Mol file: 1370000-29-5.mol

Synonyms:

Chemical Property of C₁₄H₁₁FN₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₁₁FN₂O

There total 5 articles about C₁₄H₁₁FN₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-amino-6-fluoro-3-nitrobenzoate (346691-23-4) → C14H11FN2O (1370000-29-5)

Guidance literature:

Multi-step reaction with 3 steps

1: oxone; benzaldehyde / water; N,N-dimethyl-formamide / 1 h / 20 °C

2: oxone / water; N,N-dimethyl-formamide / 1 h / 20 °C

3: diisobutylaluminium hydride / tetrahydrofuran / 1 h

With oxone; diisobutylaluminium hydride; benzaldehyde; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.01.108

Reference yield:

C15H11FN2O2 (1370000-28-4) → C14H11FN2O (1370000-29-5)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; for 1h;

DOI:10.1016/j.bmcl.2012.01.108

Reference yield:

methyl 2,6-difluorobenzoate (13671-00-6) → C14H11FN2O (1370000-29-5)

Guidance literature:

Multi-step reaction with 5 steps

1: sulfuric acid; nitric acid / 2 h

2: ammonium hydroxide / 1 h

3: oxone; benzaldehyde / water; N,N-dimethyl-formamide / 1 h / 20 °C

4: oxone / water; N,N-dimethyl-formamide / 1 h / 20 °C

5: diisobutylaluminium hydride / tetrahydrofuran / 1 h

With ammonium hydroxide; sulfuric acid; oxone; nitric acid; diisobutylaluminium hydride; benzaldehyde; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.01.108

upstream raw materials:

methyl 2-amino-6-fluoro-3-nitrobenzoate

C₁₅H₁₁FN₂O₂

methyl 2,6-difluorobenzoate

methyl 2,6-difluoro-3-nitrobenzoate

Downstream raw materials:

C₁₈H₁₈FN₃

C₁₉H₂₀FN₃

C₁₈H₁₈FN₃O

C₂₁H₂₄FN₃

Refernces