2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(3-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methoxy)benzyl)thiazol-2-yl)acetamide

Base Information

Chemical Name:2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(3-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methoxy)benzyl)thiazol-2-yl)acetamide
CAS No.:2098487-75-1
Molecular Formula:C₄₀H₄₀N₁₀O₈S₂
Molecular Weight:852.952
Hs Code.:

2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(3-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methoxy)benzyl)thiazol-2-yl)acetamide

Synonyms:

Suppliers and Price of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(3-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methoxy)benzyl)thiazol-2-yl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
PROTACSirt2Degrader-1 98.76%
10mg
$ 1500.00

ChemScene
PROTACSirt2Degrader-1 98.76%
5mg
$ 900.00

Total 8 raw suppliers

Chemical Property of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(3-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methoxy)benzyl)thiazol-2-yl)acetamide

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

PROTACSirt2Degrader-1 98.76% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(3-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methoxy)benzyl)thiazol-2-yl)acetamide

There total 3 articles about 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(3-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methoxy)benzyl)thiazol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1862237-99-7
2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(3-(prop-2-yn-1-yloxy)benzyl)thiazol-2-yl)acetamide

: 2098488-36-7
N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide

: 2098487-75-1
2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(3-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methoxy)benzyl)thiazol-2-yl)acetamide

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 - 60 ℃; for 17h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b01872

Reference yield:

: N-(4-azidobutyl)-2-chloroacetamide

: 2098487-75-1
2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(3-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methoxy)benzyl)thiazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / acetonitrile / 17 h / 20 - 60 °C

2: sodium hydroxide / ethanol; water / 1.5 h / 20 °C

3: triethylamine; dmap; dicyclohexyl-carbodiimide / 22.25 h / 0 - 20 °C / Inert atmosphere

4: sodium L-ascorbate; copper(II) sulfate / water; tert-butyl alcohol / 17 h / 20 - 60 °C / Inert atmosphere

With dmap; caesium carbonate; copper(II) sulfate; sodium L-ascorbate; triethylamine; dicyclohexyl-carbodiimide; sodium hydroxide; In ethanol; water; acetonitrile; tert-butyl alcohol; 4: |Huisgen Cycloaddition;
DOI:10.1021/acs.jmedchem.6b01872

Reference yield:

: dimethyl 3-(2-((4-azidobutyl)amino)-2-oxoethoxy)phthalate

: 2098487-75-1
2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(3-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methoxy)benzyl)thiazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol; water / 1.5 h / 20 °C

2: triethylamine; dmap; dicyclohexyl-carbodiimide / 22.25 h / 0 - 20 °C / Inert atmosphere

3: sodium L-ascorbate; copper(II) sulfate / water; tert-butyl alcohol / 17 h / 20 - 60 °C / Inert atmosphere

With dmap; copper(II) sulfate; sodium L-ascorbate; triethylamine; dicyclohexyl-carbodiimide; sodium hydroxide; In ethanol; water; tert-butyl alcohol; 3: |Huisgen Cycloaddition;
DOI:10.1021/acs.jmedchem.6b01872