13-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methyl-2-(prop-1-en-2-yl)tridecanamide

Base Information

• Chemical Name: 13-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methyl-2-(prop-1-en-2-yl)tridecanamide
• CAS No.: 1391985-75-3
• Molecular Formula: C₃₄H₅₃NO₃Si
• Molecular Weight: 551.885
• Mol file: 1391985-75-3.mol

Synonyms:

Chemical Property of 13-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methyl-2-(prop-1-en-2-yl)tridecanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 13-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methyl-2-(prop-1-en-2-yl)tridecanamide

There total 4 articles about 13-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methyl-2-(prop-1-en-2-yl)tridecanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methoxy-N-methyl-3,3-dimethylacrylamide (121712-53-6) + 11-(tert-butyldiphenylsilyloxy)-1-iodoundecane → 13-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methyl-2-(prop-1-en-2-yl)tridecanamide (1391985-75-3)

Guidance literature:

N-methoxy-N-methyl-3,3-dimethylacrylamide; With potassium hexamethylsilazane; In diethyl ether; toluene; at -78 ℃; for 0.5h;

11-(tert-butyldiphenylsilyloxy)-1-iodoundecane; In diethyl ether; toluene; at -78 ℃; for 20h;

DOI:10.1002/chem.201200882

Reference yield:

1-Bromo-11-hydroxyundecane (1611-56-9) → 13-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methyl-2-(prop-1-en-2-yl)tridecanamide (1391985-75-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1H-imidazole / dichloromethane / 12 h / 20 °C

2.1: potassium iodide / acetone / 48 h / 20 °C

3.1: potassium hexamethylsilazane / diethyl ether; toluene / 0.5 h / -78 °C

3.2: 20 h / -78 °C

With 1H-imidazole; potassium hexamethylsilazane; potassium iodide; In diethyl ether; dichloromethane; acetone; toluene; 2.1: Finkelstein reaction;

DOI:10.1002/chem.201200882

Reference yield:

11-(tert-butyldiphenylsilyloxy)undecyl bromide (172995-51-6) → 13-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methyl-2-(prop-1-en-2-yl)tridecanamide (1391985-75-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium iodide / acetone / 48 h / 20 °C

2.1: potassium hexamethylsilazane / diethyl ether; toluene / 0.5 h / -78 °C

2.2: 20 h / -78 °C

With potassium hexamethylsilazane; potassium iodide; In diethyl ether; acetone; toluene; 1.1: Finkelstein reaction;

DOI:10.1002/chem.201200882

upstream raw materials:

1-Bromo-11-hydroxyundecane

N-methoxy-N-methyl-3,3-dimethylacrylamide

tert-butylchlorodiphenylsilane

11-(tert-butyldiphenylsilyloxy)undecyl bromide