(E)-5-benzyl-3-(3-(4-hydroxyphenyl)allyl)-7-isopropyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

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Chemical Name:(E)-5-benzyl-3-(3-(4-hydroxyphenyl)allyl)-7-isopropyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS No.:1376709-49-7
Molecular Formula:C₂₉H₃₀N₂O₃S
Molecular Weight:486.635
Hs Code.:

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Chemical Property of (E)-5-benzyl-3-(3-(4-hydroxyphenyl)allyl)-7-isopropyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

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Technology Process of (E)-5-benzyl-3-(3-(4-hydroxyphenyl)allyl)-7-isopropyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

There total 11 articles about (E)-5-benzyl-3-(3-(4-hydroxyphenyl)allyl)-7-isopropyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1376709-56-6
C₃₇H₅₀N₂O₄SSi

: 1376709-49-7
(E)-5-benzyl-3-(3-(4-hydroxyphenyl)allyl)-7-isopropyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: C₃₇H₅₀N₂O₄SSi; With sodium methylate; In methanol; for 3h; Reflux;

In methanol;
DOI:10.1016/j.ejmech.2012.02.035

Reference yield:

: 7400-08-0,50940-26-6
p-Coumaric Acid

: 1376709-49-7
(E)-5-benzyl-3-(3-(4-hydroxyphenyl)allyl)-7-isopropyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

2.1: diisobutylaluminium hydride / dichloromethane; toluene / 8 h / -78 °C

2.2: 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 3 h / 20 °C

4.1: sodium azide / N,N-dimethyl-formamide / 5 h / 20 °C

5.1: hydrogen / ethanol / 5 h / 20 °C / 760.05 Torr

6.1: pyridine; dmap / tetrahydrofuran / 20 °C

7.1: sodium methylate / methanol / 3 h / Reflux

7.2: Dowex H⁺ resin

With pyridine; 1H-imidazole; dmap; sodium azide; hydrogen; sodium methylate; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2012.02.035

Reference yield:

: 5432-85-9
4-isopropyl-cyclohexanone

: 1376709-49-7
(E)-5-benzyl-3-(3-(4-hydroxyphenyl)allyl)-7-isopropyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane; toluene / 0.5 h / -20 °C

1.2: 18 h / -78 - -45 °C

2.1: morpholine; sulfur / ethanol / 48 h / Reflux

3.1: pyridine / dichloromethane / 12.25 h / 20 °C

4.1: pyridine; dmap / tetrahydrofuran / 20 °C

5.1: sodium methylate / methanol / 3 h / Reflux

5.2: Dowex H⁺ resin

With morpholine; pyridine; sulfur; dmap; n-butyllithium; sodium methylate; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; toluene; 2.1: Gewald reaction;
DOI:10.1016/j.ejmech.2012.02.035