8-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(3,4-dichlorophenyl)-2,5-methano-2,3,4,5-tetrahydro-1H-benzo[c]azepine

Base Information

Chemical Name:8-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(3,4-dichlorophenyl)-2,5-methano-2,3,4,5-tetrahydro-1H-benzo[c]azepine
CAS No.:1360439-72-0
Molecular Formula:C₂₃H₁₈Cl₂N₄
Molecular Weight:421.329
Hs Code.:

Synonyms:

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Chemical Property of 8-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(3,4-dichlorophenyl)-2,5-methano-2,3,4,5-tetrahydro-1H-benzo[c]azepine

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Technology Process of 8-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(3,4-dichlorophenyl)-2,5-methano-2,3,4,5-tetrahydro-1H-benzo[c]azepine

There total 8 articles about 8-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(3,4-dichlorophenyl)-2,5-methano-2,3,4,5-tetrahydro-1H-benzo[c]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 356560-80-0
6-bromo[1,2,4]triazolo[1,5-a]pyridine

: C₂₃H₂₆BCl₂NO₂

: 1360439-72-0,1360439-74-2,1360439-83-3
8-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(3,4-dichlorophenyl)-2,5-methano-2,3,4,5-tetrahydro-1H-benzo[c]azepine

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; at 90 ℃; for 3h; Inert atmosphere;

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 1360439-72-0,1360439-74-2,1360439-83-3
8-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(3,4-dichlorophenyl)-2,5-methano-2,3,4,5-tetrahydro-1H-benzo[c]azepine

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0 - 45 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 4.25 h / -78 °C

2.2: -78 - 20 °C

3.1: isopropylmagnesium bromide / tetrahydrofuran / 2 h / 20 °C

3.2: 2 h / 0 - 20 °C

4.1: trifluorormethanesulfonic acid / dichloromethane / 3.5 h

5.1: hydrogen bromide / water; acetic acid / 12 h / 135 °C

5.2: pH 7 - 8

6.1: pyridine / dichloromethane / 12 h / 0 - 20 °C

7.1: potassium acetate / N,N-dimethyl-formamide / 0.08 h / Inert atmosphere

7.2: 2 h / 80 °C

8.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 3 h / 90 °C / Inert atmosphere

With pyridine; oxalyl dichloride; trifluorormethanesulfonic acid; hydrogen bromide; isopropylmagnesium bromide; potassium acetate; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; dimethyl sulfoxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane; water; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1-(3-methoxybenzyl)pyrrolidine-3-one

: 1360439-72-0,1360439-74-2,1360439-83-3
8-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(3,4-dichlorophenyl)-2,5-methano-2,3,4,5-tetrahydro-1H-benzo[c]azepine

Guidance literature:: Multi-step reaction with 6 steps

1.1: isopropylmagnesium bromide / tetrahydrofuran / 2 h / 20 °C

1.2: 2 h / 0 - 20 °C

2.1: trifluorormethanesulfonic acid / dichloromethane / 3.5 h

3.1: hydrogen bromide / water; acetic acid / 12 h / 135 °C

3.2: pH 7 - 8

4.1: pyridine / dichloromethane / 12 h / 0 - 20 °C

5.1: potassium acetate / N,N-dimethyl-formamide / 0.08 h / Inert atmosphere

5.2: 2 h / 80 °C

6.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 3 h / 90 °C / Inert atmosphere

With pyridine; trifluorormethanesulfonic acid; hydrogen bromide; isopropylmagnesium bromide; potassium acetate; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;