C₆⁽¹³⁾C₉H₁₁I₄⁽¹⁵⁾NO₄

Base Information

Chemical Name:C₆⁽¹³⁾C₉H₁₁I₄⁽¹⁵⁾NO₄
CAS No.:1431868-11-9
Molecular Formula:C₁₅H₁₁I₄NO₄
Molecular Weight:786.769
Hs Code.:

C<sub>6</sub><sup>(13)</sup>C<sub>9</sub>H<sub>11</sub>I<sub>4</sub><sup>(15)</sup>NO<sub>4</sub>

Synonyms:

Suppliers and Price of C₆⁽¹³⁾C₉H₁₁I₄⁽¹⁵⁾NO₄

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
ThyroxineCarboxy,α,β,1,2,3,4,5,6-13C9,15N
2.5mg
$ 1755.00

TRC
ThyroxineCarboxy,α,β,1,2,3,4,5,6-13C9,15N
1mg
$ 825.00

Cayman Chemical
L-Thyroxine-13C9,15N ≥98%
1mg
$ 750.00

AK Scientific
(2S)-2-(15N)Azanyl-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo(1,2,3,4,5,6-13C6)cyclohexa-1,3,5-trien-1-yl](1,2,3-13C3)propanoicacid
1mg
$ 1112.00

Total 5 raw suppliers

Chemical Property of C₆⁽¹³⁾C₉H₁₁I₄⁽¹⁵⁾NO₄

Chemical Property:

Purity/Quality:

> 95% ^*data from raw suppliers

ThyroxineCarboxy,α,β,1,2,3,4,5,6-13C9,15N ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description L-Thyroxine-13C9,15N is intended for use as an internal standard for the quantification of L-thyroxine by GC- or LC-MS. L-Thyroxine is a synthetic form of the thyroid hormone thyroxine. In vivo, L-thyroxine (0.9 and 2.7 μg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone from the anterior pituitary in mice. It also reverses decreases in levels of circulating thymic serum factor (FTS) and the number of T rosette-forming cells in an old age-induced mouse model of hypothyroidism. Formulations containing L-thyroxine have been used in the treatment of hypothyroidism.
Uses Thyroxine Carboxy,α,β,1,2,3,4,5,6-13C9,15N is 13C and 15N labeled analogue of Thyroxine (T425600), which is one of the thyroid hormones involved in the maintenance of metabolic homeostasis.

Technology Process of C₆⁽¹³⁾C₉H₁₁I₄⁽¹⁵⁾NO₄

There total 8 articles about C₆⁽¹³⁾C₉H₁₁I₄⁽¹⁵⁾NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₁⁽¹³⁾C₉H₁₉I₄⁽¹⁵⁾NO₆

: 1431868-11-9,720710-30-5
C₆⁽¹³⁾C₉H₁₁I₄⁽¹⁵⁾NO₄

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; Inert atmosphere;
DOI:10.1080/00397911.2011.639005

Reference yield:

: 1431868-04-0
C₆⁽¹³⁾C₉H₁₉I₂⁽¹⁵⁾NO₅

: 1431868-11-9,720710-30-5
C₆⁽¹³⁾C₉H₁₁I₄⁽¹⁵⁾NO₄

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C

3: Iodine monochloride; N-butylamine / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 °C

4: lithium hydroxide / water; methanol / 1.5 h / 4 °C

5: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; tetrabutyl ammonium fluoride; copper diacetate; Iodine monochloride; N-butylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1080/00397911.2011.639005

Reference yield:

: 1431868-03-9
C₆⁽¹³⁾C₉H₂₁⁽¹⁵⁾NO₅

: 1431868-11-9,720710-30-5
C₆⁽¹³⁾C₉H₁₁I₄⁽¹⁵⁾NO₄

Guidance literature:: Multi-step reaction with 6 steps

1: N-iodo-succinimide / dichloromethane / 0.67 h / 0 °C

2: N-ethyl-N,N-diisopropylamine; pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 - 20 °C

4: Iodine monochloride; N-butylamine / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 0 °C

5: lithium hydroxide / water; methanol / 1.5 h / 4 °C

6: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; N-iodo-succinimide; tetrabutyl ammonium fluoride; copper diacetate; Iodine monochloride; N-butylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1080/00397911.2011.639005