Technology Process of tert-butyl 4-[(4-bromophenyl)ethynyl]-1-(3-bromopropyl)-4-hydroxy-2-methylcyclohexa-2,5-dienecarboxylate
There total 1 articles about tert-butyl 4-[(4-bromophenyl)ethynyl]-1-(3-bromopropyl)-4-hydroxy-2-methylcyclohexa-2,5-dienecarboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-bromo-1-ethynylbenzene;
With
lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
1-(3-bromopropyl)-2-methyl-4-oxocyclohexa-2,5-dienecarboxylic acid tert-butyl ester;
In
tetrahydrofuran; hexane;
for 2h;
With
water; ammonium chloride;
In
tetrahydrofuran; hexane;
DOI:10.1021/jo8015192
