C₂₂H₂₁FN₆O₂

Base Information

• Chemical Name: C₂₂H₂₁FN₆O₂
• CAS No.: 1649449-59-1
• Molecular Formula: C₂₂H₂₁FN₆O₂
• Molecular Weight: 420.446
• Mol file: 1649449-59-1.mol

Synonyms:

Chemical Property of C₂₂H₂₁FN₆O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₁FN₆O₂

There total 5 articles about C₂₂H₂₁FN₆O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Chloroacetyl-6-fluoroindole (77261-73-5) → C22H21FN6O2 (1649449-59-1)

Guidance literature:

Multi-step reaction with 5 steps

1: hexamethylenetetramine / Reflux

2: hydrazine hydrate / ethanol / 12 h / Reflux

3: potassium hydroxide / ethanol / 40 h / 0 °C / Reflux

4: ethyl acetate / 25 h / 20 °C

5: ethanol / 0.18 h / Microwave irradiation

With hexamethylenetetramine; hydrazine hydrate; potassium hydroxide; In ethanol; ethyl acetate;

DOI:10.1002/jhet.1621

Reference yield:

7-fluoro-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-5-carbohydrazide (1649449-33-1) → C22H21FN6O2 (1649449-59-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol / 40 h / 0 °C / Reflux

2: ethyl acetate / 25 h / 20 °C

3: ethanol / 0.18 h / Microwave irradiation

With potassium hydroxide; In ethanol; ethyl acetate;

DOI:10.1002/jhet.1621

Reference yield:

6-fluoroisatin (324-03-8) → C22H21FN6O2 (1649449-59-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 5 h / Reflux

2: hexamethylenetetramine / Reflux

3: hydrazine hydrate / ethanol / 12 h / Reflux

4: potassium hydroxide / ethanol / 40 h / 0 °C / Reflux

5: ethyl acetate / 25 h / 20 °C

6: ethanol / 0.18 h / Microwave irradiation

With hexamethylenetetramine; hydrazine hydrate; potassium hydroxide; In ethanol; ethyl acetate;

DOI:10.1002/jhet.1621

upstream raw materials:

N-Chloroacetyl-6-fluoroindole

6-fluoroisatin

7-fluoro-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-5-carbohydrazide

7-fluoro-5-(5-mercapto-1,3,4-oxadiazol-2-yl)-1H-1,4-benzodiazepin-2(3H)-one