C₂₈H₃₈N₄O₄

Base Information

• Chemical Name: C₂₈H₃₈N₄O₄
• CAS No.: 874333-05-8
• Molecular Formula: C₂₈H₃₈N₄O₄
• Molecular Weight: 494.634
• Mol file: 874333-05-8.mol

Synonyms:

Chemical Property of C₂₈H₃₈N₄O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₃₈N₄O₄

There total 10 articles about C₂₈H₃₈N₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{3-[2-(2-hydroxy-ethoxy)-phenyl]-propyl}-carbamic acid 1-(3,5-dimethoxy-phenyl)-1-methyl-ethyl ester (811867-17-1) + C15H21NO6 (1122565-94-9) + C12H14N2O4S2 (1365999-57-0) + Ddz-L-Phe-OH (39508-07-1) → C28H38N4O4 (874333-05-8)

Guidance literature:

Ddz-L-Phe-OH; With triethylsilane; N,N-diethyl-N-isopropylamine; C₂₃H₂₂NOPolS; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane; at 20 ℃; Inert atmosphere; solid phase reaction;

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; Inert atmosphere; solid phase reaction;

{3-[2-(2-hydroxy-ethoxy)-phenyl]-propyl}-carbamic acid 1-(3,5-dimethoxy-phenyl)-1-methyl-ethyl ester; C₁₅H₂₁NO₆; C₁₂H₁₄N₂O₄S₂; Further stages;

DOI:10.1021/jm2007062

Reference yield:

C16H21N3O3 → C28H38N4O4 (874333-05-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triphenylphosphine / water / 20 °C / Inert atmosphere

2.1: hydrogenchloride / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; trimethyl gallium / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

4.1: palladium on activated charcoal; hydrogen / ethanol / 20 °C / Inert atmosphere

5.1: triethylsilane; C₂₃H₂₂NOPolS; N,N-diethyl-N-isopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; trifluoroacetic acid / 1-methyl-pyrrolidin-2-one; dichloromethane / 20 °C / Inert atmosphere; solid phase reaction

5.2: 20 °C / Inert atmosphere; solid phase reaction

With hydrogenchloride; triethylsilane; N,N-diethyl-N-isopropylamine; C₂₃H₂₂NOPolS; palladium on activated charcoal; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; trimethyl gallium; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm2007062

Reference yield:

C17H24O6S → C28H38N4O4 (874333-05-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium azide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.1: triphenylphosphine / water / 20 °C / Inert atmosphere

3.1: hydrogenchloride / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; trimethyl gallium / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

5.1: palladium on activated charcoal; hydrogen / ethanol / 20 °C / Inert atmosphere

6.1: triethylsilane; C₂₃H₂₂NOPolS; N,N-diethyl-N-isopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; trifluoroacetic acid / 1-methyl-pyrrolidin-2-one; dichloromethane / 20 °C / Inert atmosphere; solid phase reaction

6.2: 20 °C / Inert atmosphere; solid phase reaction

With hydrogenchloride; triethylsilane; sodium azide; N,N-diethyl-N-isopropylamine; C₂₃H₂₂NOPolS; palladium on activated charcoal; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; trimethyl gallium; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm2007062

upstream raw materials:

{3-[2-(2-hydroxy-ethoxy)-phenyl]-propyl}-carbamic acid 1-(3,5-dimethoxy-phenyl)-1-methyl-ethyl ester

C₁₅H₂₁NO₆

C₁₂H₁₄N₂O₄S₂

Ddz-L-Phe-OH