3-<3(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-3-hydroxy-2(R)-cyclohexylmethyl-1-oxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

Base Information

Chemical Name:3-<3(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-3-hydroxy-2(R)-cyclohexylmethyl-1-oxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone
CAS No.:134458-68-7
Molecular Formula:C₃₇H₅₆N₂O₇
Molecular Weight:640.861
Hs Code.:

3-<3(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-3-hydroxy-2(R)-cyclohexylmethyl-1-oxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

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Chemical Property of 3-<3(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-3-hydroxy-2(R)-cyclohexylmethyl-1-oxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

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Technology Process of 3-<3(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-3-hydroxy-2(R)-cyclohexylmethyl-1-oxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

There total 1 articles about 3-<3(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-3-hydroxy-2(R)-cyclohexylmethyl-1-oxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117997-58-7
tert-butyl (4S,5R)-4-(cyclohexylmethyl)-5-formyl-2,2-dimethyl-3-oxazolidinecarboxylate

: 134458-53-0
(4R,5S)-3-(3-Cyclohexyl-propionyl)-4-methyl-5-phenyl-oxazolidin-2-one

: 134458-68-7
3-<3(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-3-hydroxy-2(R)-cyclohexylmethyl-1-oxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

Guidance literature:: Yield given. Multistep reaction;
DOI:10.1021/jm00112a005

Reference yield:

: 134458-68-7
3-<3(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-3-hydroxy-2(R)-cyclohexylmethyl-1-oxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

: 134458-72-3
3(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-3-hydroxy-2(R)-(cyclohexylmethyl)propanoic acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In methanol; for 4h; Ambient temperature;
DOI:10.1021/jm00112a005

Reference yield:

: 134458-68-7
3-<3(R)-<3-(tert-butyloxycarbonyl)-4(S)-(cyclohexylmethyl)-2,2-dimethyl-5(R)-oxazolidinyl>-3-hydroxy-2(R)-cyclohexylmethyl-1-oxopropyl>-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

: (2R,3R,4R,5S)-5-Amino-6-cyclohexyl-2-cyclohexylmethyl-3,4-dihydroxy-hexanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1: aq. hydrogen peroxide, aq. lithium hydroxide / methanol / 4 h / Ambient temperature

2: 1.) camphorsulfonic acid, 2.) acetone / 1.) CH₂Cl₂, RT, 45 min, 2.) CH₂Cl₂, RT, 14 h

3: diisopropylethylamine, diethylphosphoryl cyanide / CH₂Cl₂ / 14 h / Ambient temperature

4: acetyl chloride, ethanedithiol / methanol / 5 h

With ethandithiol; lithium hydroxide; diethylphosphoryl cyanide; camphor-10-sulfonic acid; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; acetyl chloride; acetone; In methanol; dichloromethane;
DOI:10.1021/jm00112a005