(1S,4R)-1-<(1E,3S,4R)-3-(benzyloxy)-6-(tert-butyldimethylsilyloxy)-4-hydroxy-3-(hydroxymethyl)-1-hexenyl>-7,7-dimethylbicyclo<2.2.1>-heptan-2-one

Base Information

Chemical Name:(1S,4R)-1-<(1E,3S,4R)-3-(benzyloxy)-6-(tert-butyldimethylsilyloxy)-4-hydroxy-3-(hydroxymethyl)-1-hexenyl>-7,7-dimethylbicyclo<2.2.1>-heptan-2-one
CAS No.:220325-45-1
Molecular Formula:C₂₉H₄₆O₅Si
Molecular Weight:502.767
Hs Code.:

(1S,4R)-1-<(1E,3S,4R)-3-(benzyloxy)-6-(tert-butyldimethylsilyloxy)-4-hydroxy-3-(hydroxymethyl)-1-hexenyl>-7,7-dimethylbicyclo<2.2.1>-heptan-2-one

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Chemical Property of (1S,4R)-1-<(1E,3S,4R)-3-(benzyloxy)-6-(tert-butyldimethylsilyloxy)-4-hydroxy-3-(hydroxymethyl)-1-hexenyl>-7,7-dimethylbicyclo<2.2.1>-heptan-2-one

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Technology Process of (1S,4R)-1-<(1E,3S,4R)-3-(benzyloxy)-6-(tert-butyldimethylsilyloxy)-4-hydroxy-3-(hydroxymethyl)-1-hexenyl>-7,7-dimethylbicyclo<2.2.1>-heptan-2-one

There total 6 articles about (1S,4R)-1-<(1E,3S,4R)-3-(benzyloxy)-6-(tert-butyldimethylsilyloxy)-4-hydroxy-3-(hydroxymethyl)-1-hexenyl>-7,7-dimethylbicyclo<2.2.1>-heptan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 220325-38-2
(3aR,5R,6R,6aR)-tetrahydro-6-hydroxy-6-<(E)-2-<(1S,2R,4R)-2-hydroxy-7,7-dimethylbicyclo<2.2.1>hept-1-yl>vinyl>-2,2-dimethylfuro<2,3-d>-1,3-dioxole-5-ethanol

: 220325-45-1
(1S,4R)-1-<(1E,3S,4R)-3-(benzyloxy)-6-(tert-butyldimethylsilyloxy)-4-hydroxy-3-(hydroxymethyl)-1-hexenyl>-7,7-dimethylbicyclo<2.2.1>-heptan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / imidazole / CH₂Cl₂ / 1 h / 0 °C

2: 98 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h

3: 89 percent / NaH, tetra-n-butylammonium iodide / dimethylformamide / 4 h / Ambient temperature

4: 43 percent / TiCl₄ / CH₂Cl₂ / -78 °C

5: 1) Dess-Martin periodinane, 2) NaBH₄ / 1) CH₂Cl₂, 0 deg C, 30 min, 2) methanol, -40 deg C, 1 h

With 1H-imidazole; sodium tetrahydroborate; titanium tetrachloride; tetra-(n-butyl)ammonium iodide; sodium hydride; Dess-Martin periodane; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo982002w

Reference yield:

: 220325-39-3
(3aR,5R,6R,6aR)-5-<2-(tert-butyldimethylsilyloxy)ethyl>-tetrahydro-6-<(E)-2-<(1S,2R,4R)-2-hydroxy-7,7-dimethylbicyclo<2.2.1>hept-1-yl>vinyl>-2,2-dimethylfuro<2,3-d>-1,3-dioxol-6-ol

: 220325-45-1
(1S,4R)-1-<(1E,3S,4R)-3-(benzyloxy)-6-(tert-butyldimethylsilyloxy)-4-hydroxy-3-(hydroxymethyl)-1-hexenyl>-7,7-dimethylbicyclo<2.2.1>-heptan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h

2: 89 percent / NaH, tetra-n-butylammonium iodide / dimethylformamide / 4 h / Ambient temperature

3: 43 percent / TiCl₄ / CH₂Cl₂ / -78 °C

4: 1) Dess-Martin periodinane, 2) NaBH₄ / 1) CH₂Cl₂, 0 deg C, 30 min, 2) methanol, -40 deg C, 1 h

With sodium tetrahydroborate; titanium tetrachloride; tetra-(n-butyl)ammonium iodide; sodium hydride; Dess-Martin periodane; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo982002w

Reference yield:

: 220325-41-7
(1S,4R)-1-<(E)-2-<(3aR,5R,6R,6aR)-5-<2-(tert-butyldimethylsilyloxy)ethyl>-tetrahydro-6-hydroxy-2,2-dimethylfuro<2,3-d>-1,3-dioxol-6-yl>vinyl>-7,7-dimethylbicyclo<2.2.1>-heptan-2-one

: 220325-45-1
(1S,4R)-1-<(1E,3S,4R)-3-(benzyloxy)-6-(tert-butyldimethylsilyloxy)-4-hydroxy-3-(hydroxymethyl)-1-hexenyl>-7,7-dimethylbicyclo<2.2.1>-heptan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / NaH, tetra-n-butylammonium iodide / dimethylformamide / 4 h / Ambient temperature

2: 43 percent / TiCl₄ / CH₂Cl₂ / -78 °C

3: 1) Dess-Martin periodinane, 2) NaBH₄ / 1) CH₂Cl₂, 0 deg C, 30 min, 2) methanol, -40 deg C, 1 h

With sodium tetrahydroborate; titanium tetrachloride; tetra-(n-butyl)ammonium iodide; sodium hydride; Dess-Martin periodane; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo982002w