Boc-PheΨGly-AHPPA-Leu-NHCH2Ph

Base Information

• Chemical Name: Boc-PheΨGly-AHPPA-Leu-NHCH2Ph
• CAS No.: 118404-85-6
• Molecular Formula: C₄₁H₅₄N₄O₆
• Molecular Weight: 698.903

Synonyms:

Chemical Property of Boc-PheΨGly-AHPPA-Leu-NHCH2Ph

Chemical Property:

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Technology Process of Boc-PheΨGly-AHPPA-Leu-NHCH2Ph

There total 2 articles about Boc-PheΨGly-AHPPA-Leu-NHCH2Ph which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-5-<(tert-Butoxycarbonyl)amino>-6-phenyl-(E)-3-hexenoic acid (82042-48-6) → Boc-PheΨGly-AHPPA-Leu-NHCH2Ph (118404-85-6,124338-83-6)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 1.) 0 deg C, 0.5 h, 2.) room temp.;

DOI:10.1021/jm00164a058

Reference yield:

(E)-(S)-<1-(phenylmethyl)-5-(trimethylsilyl)-3-hexen-5-ynyl>carbamic acid 1,1-dimethylethyl ester (82001-64-7) → Boc-PheΨGly-AHPPA-Leu-NHCH2Ph (118404-85-6,124338-83-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) (cyclohexyl)2BH, 2.) 2 N NaOH, 30percent H₂O₂ / 1.) THF, 0 deg C, 1 h, 2.) MeOH, room temp., 1 h

2: HOBT/DCC, Et₃N / dimethylformamide / 1.) 0 deg C, 0.5 h, 2.) room temp.

With sodium hydroxide; bis(cyclohexanyl)borane; dihydrogen peroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1021/jm00164a058

Reference yield:

Boc-PheΨGly-AHPPA-Leu-NHCH2Ph (118404-85-6,124338-83-6) → [(S)-1-(3-{[(1S,2S)-1-Benzyl-3-((S)-1-benzylcarbamoyl-3-methyl-butylcarbamoyl)-2-hydroxy-propylcarbamoyl]-methyl}-oxiranyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester (118404-91-4,124338-88-1,124339-19-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 72h; Ambient temperature;

DOI:10.1021/jm00164a058

upstream raw materials:

(S)-5-<(tert-Butoxycarbonyl)amino>-6-phenyl-(E)-3-hexenoic acid

(E)-(S)-<1-(phenylmethyl)-5-(trimethylsilyl)-3-hexen-5-ynyl>carbamic acid 1,1-dimethylethyl ester

Downstream raw materials:

[(S)-1-(3-{[(1S,2S)-1-Benzyl-3-((S)-1-benzylcarbamoyl-3-methyl-butylcarbamoyl)-2-hydroxy-propylcarbamoyl]-methyl}-oxiranyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

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