aplyronine D

Base Information

• Chemical Name: aplyronine D
• CAS No.: 1124380-02-4
• Molecular Formula: C₅₈H₉₉N₃O₁₄
• Molecular Weight: 1062.44
• Mol file: 1124380-02-4.mol

Synonyms:

Chemical Property of aplyronine D

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of aplyronine D

There total 12 articles about aplyronine D which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

aplyronine I + N,N,O-trimethylserine → aplyronine D (1124380-02-4)

Guidance literature:

With dmap; 2,4,6-trichlorobenzoyl chloride; triethylamine; In dichloromethane; benzene; at 0 ℃; Inert atmosphere;

DOI:10.1039/c7ob03204h

Reference yield:

C66H121NO12Si3 → aplyronine D (1124380-02-4)

Guidance literature:

Multi-step reaction with 6 steps

1: Burgess Reagent / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2: triphenylphosphine; copper(II) acetate monohydrate; 1,1,3,3-Tetramethyldisiloxane / toluene / 5 h / 20 °C / Inert atmosphere

3: zinc(II) tetrahydroborate / diethyl ether / 11 h / 0 °C

4: triethylamine; 2,4,6-trichlorobenzoyl chloride; dmap / tetrahydrofuran; toluene / 2 h / 20 °C / Inert atmosphere

5: pyridine hydrogenfluoride; pyridine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

6: triethylamine; 2,4,6-trichlorobenzoyl chloride; dmap / benzene; dichloromethane / 0 °C / Inert atmosphere

With pyridine; dmap; zinc(II) tetrahydroborate; Burgess Reagent; 1,1,3,3-Tetramethyldisiloxane; 2,4,6-trichlorobenzoyl chloride; copper(II) acetate monohydrate; pyridine hydrogenfluoride; triethylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; benzene;

DOI:10.1039/c7ob03204h

Reference yield:

C66H119NO11Si3 (1440972-81-5) → aplyronine D (1124380-02-4)

Guidance literature:

Multi-step reaction with 5 steps

1: triphenylphosphine; copper(II) acetate monohydrate; 1,1,3,3-Tetramethyldisiloxane / toluene / 5 h / 20 °C / Inert atmosphere

2: zinc(II) tetrahydroborate / diethyl ether / 11 h / 0 °C

3: triethylamine; 2,4,6-trichlorobenzoyl chloride; dmap / tetrahydrofuran; toluene / 2 h / 20 °C / Inert atmosphere

4: pyridine hydrogenfluoride; pyridine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

5: triethylamine; 2,4,6-trichlorobenzoyl chloride; dmap / benzene; dichloromethane / 0 °C / Inert atmosphere

With pyridine; dmap; zinc(II) tetrahydroborate; 1,1,3,3-Tetramethyldisiloxane; 2,4,6-trichlorobenzoyl chloride; copper(II) acetate monohydrate; pyridine hydrogenfluoride; triethylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; benzene;

DOI:10.1039/c7ob03204h

upstream raw materials:

C₆₆H₁₁₉NO₁₁Si₃

C₆₆H₁₂₁NO₁₁Si₃

C₆₆H₁₂₃NO₁₁Si₃

C₅₃H₁₀₂O₈Si₃