Technology Process of 1-{1-[(2'-{[(1R)-3-{[tert-butyl(diphenyl)silyl]oxy}-1-methylpropyl]oxy}-3-fluorobiphenyl-4-yl)carbonyl]piperidin-4-yl}-7-ethyl-3,3-dimethyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one
There total 7 articles about 1-{1-[(2'-{[(1R)-3-{[tert-butyl(diphenyl)silyl]oxy}-1-methylpropyl]oxy}-3-fluorobiphenyl-4-yl)carbonyl]piperidin-4-yl}-7-ethyl-3,3-dimethyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 5 h / Reflux
2.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 20 °C
3.1: hydrogen / palladium hydroxide, 20 wt% on carbon / tetrahydrofuran / 20 °C
4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
4.2: 20 °C
With
di-tert-butyl-diazodicarboxylate; hydrogen; sodium carbonate; triphenylphosphine; trifluoroacetic acid;
tetrakis(triphenylphosphine) palladium(0); palladium hydroxide, 20 wt% on carbon;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;
1.1: Suzuki-Miyaura reaction / 2.1: Mitsunobu reaction;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 20 °C / cooling with ice
2.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 20 °C
3.1: hydrogen / palladium hydroxide, 20 wt% on carbon / tetrahydrofuran / 20 °C
4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
4.2: 20 °C
With
di-tert-butyl-diazodicarboxylate; hydrogen; triethylamine; triphenylphosphine; trifluoroacetic acid;
palladium hydroxide, 20 wt% on carbon;
In
tetrahydrofuran; dichloromethane;
2.1: Mitsunobu reaction;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C
2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 5 h / Reflux
3.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 20 °C
4.1: hydrogen / palladium hydroxide, 20 wt% on carbon / tetrahydrofuran / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
5.2: 20 °C
With
di-tert-butyl-diazodicarboxylate; hydrogen; sodium carbonate; potassium carbonate; triphenylphosphine; trifluoroacetic acid;
tetrakis(triphenylphosphine) palladium(0); palladium hydroxide, 20 wt% on carbon;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;
2.1: Suzuki-Miyaura reaction / 3.1: Mitsunobu reaction;
