2-{2-[1-[2-(4-Diethylamino-phenylazo)-4-trifluoromethyl-thiazol-5-yl]-1-piperidin-1-yl-meth-(E)-ylidene]-3-oxo-indan-1-ylidene}-malononitrile

Base Information

• Chemical Name: 2-{2-[1-[2-(4-Diethylamino-phenylazo)-4-trifluoromethyl-thiazol-5-yl]-1-piperidin-1-yl-meth-(E)-ylidene]-3-oxo-indan-1-ylidene}-malononitrile
• CAS No.: 137929-18-1
• Molecular Formula: C₃₂H₂₈F₃N₇OS
• Molecular Weight: 615.682
• Mol file: 137929-18-1.mol

Synonyms:

Chemical Property of 2-{2-[1-[2-(4-Diethylamino-phenylazo)-4-trifluoromethyl-thiazol-5-yl]-1-piperidin-1-yl-meth-(E)-ylidene]-3-oxo-indan-1-ylidene}-malononitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{2-[1-[2-(4-Diethylamino-phenylazo)-4-trifluoromethyl-thiazol-5-yl]-1-piperidin-1-yl-meth-(E)-ylidene]-3-oxo-indan-1-ylidene}-malononitrile

There total 4 articles about 2-{2-[1-[2-(4-Diethylamino-phenylazo)-4-trifluoromethyl-thiazol-5-yl]-1-piperidin-1-yl-meth-(E)-ylidene]-3-oxo-indan-1-ylidene}-malononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

piperidine (110-89-4) + 3-(1,1-dicyanomethylene)-indanone (1080-74-6) + 2-(4-N,N-Diethylamino)phenylazo-4-trifluoromethylthiazole-5-carbaldehyde (137953-59-4) → 2-{2-[1-[2-(4-Diethylamino-phenylazo)-4-trifluoromethyl-thiazol-5-yl]-1-piperidin-1-yl-meth-(E)-ylidene]-3-oxo-indan-1-ylidene}-malononitrile (137929-18-1)

Guidance literature:

for 17h; Heating;

Reference yield:

ethyl 2-amino-4-(trifluoromethyl)-5-thiazole-carboxylate (344-72-9) → 2-{2-[1-[2-(4-Diethylamino-phenylazo)-4-trifluoromethyl-thiazol-5-yl]-1-piperidin-1-yl-meth-(E)-ylidene]-3-oxo-indan-1-ylidene}-malononitrile (137929-18-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) nitrosylsulfuric acid / 1) acetic acid, 30 min, 2) acetic acid, 15-20 deg C, 15 h

2: 56 percent / LiAlH₄ / diethyl ether / 15 h / -10 °C

3: 84 percent / MnO₂ / diethyl ether / 5 h / Ambient temperature

4: 33 percent / 17 h / Heating

With manganese(IV) oxide; lithium aluminium tetrahydride; nitrosylsulfuric acid; In diethyl ether;

Reference yield:

2-(4-N,N-Diethylamino)phenylazo-5-hydroxymethyl-4-trifluoromethylthiazole (137929-16-9) → 2-{2-[1-[2-(4-Diethylamino-phenylazo)-4-trifluoromethyl-thiazol-5-yl]-1-piperidin-1-yl-meth-(E)-ylidene]-3-oxo-indan-1-ylidene}-malononitrile (137929-18-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / MnO₂ / diethyl ether / 5 h / Ambient temperature

2: 33 percent / 17 h / Heating

With manganese(IV) oxide; In diethyl ether;

upstream raw materials:

piperidine

3-(1,1-dicyanomethylene)-indanone

2-(4-N,N-Diethylamino)phenylazo-4-trifluoromethylthiazole-5-carbaldehyde

ethyl 2-amino-4-(trifluoromethyl)-5-thiazole-carboxylate