4,4-Bis(phenylthio)-1-(m-methylphenyl)-3-butenol

Base Information

• Chemical Name: 4,4-Bis(phenylthio)-1-(m-methylphenyl)-3-butenol
• CAS No.: 157953-95-2
• Molecular Formula: C₂₃H₂₂OS₂
• Molecular Weight: 378.559
• Mol file: 157953-95-2.mol

Synonyms:

Chemical Property of 4,4-Bis(phenylthio)-1-(m-methylphenyl)-3-butenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4-Bis(phenylthio)-1-(m-methylphenyl)-3-butenol

There total 1 articles about 4,4-Bis(phenylthio)-1-(m-methylphenyl)-3-butenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methylketene diphenyldithioacetal (71341-78-1) + m-tolyl aldehyde (620-23-5) → 4,4-Bis(phenylthio)-1-(m-methylphenyl)-3-butenol (157953-95-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; Yield given; 1.) -20 deg C, 30 min, 2.) -78 deg C, 10 min;

DOI:10.1021/jo00099a036

Reference yield:

acetic anhydride (108-24-7) + 4,4-Bis(phenylthio)-1-(m-methylphenyl)-3-butenol (157953-95-2) → 4,4-Bis(phenylthio)-1-(m-methylphenyl)-3-butenyl acetate (157954-77-3)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 25 ℃; for 1h; Yield given;

DOI:10.1021/jo00099a036

Reference yield:

4,4-Bis(phenylthio)-1-(m-methylphenyl)-3-butenol (157953-95-2) → (R)-4,4-Bis(phenylthio)-1-(m-methylphenyl)-3-butenol

Guidance literature:

Multi-step reaction with 2 steps

1: DMAP, Et₃N / CH₂Cl₂ / 1 h / 25 °C

2: dimethylformamide / 130 h / 25 - 27 °C / lipase MY (Candida cylindracea), phosphate buffer (pH 7.5)

With dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo00099a036

upstream raw materials:

methylketene diphenyldithioacetal

m-tolyl aldehyde

Downstream raw materials:

4,4-Bis(phenylthio)-1-(m-methylphenyl)-3-butenyl acetate